贝伐单抗与 ziv-aflibercept 治疗视网膜分支静脉阻塞的比较。
Bevacizumab versus ziv-aflibercept in branch retinal vein occlusion.
机构信息
Department of Surgery, School of Medicine and Dentistry, University of Ghana; Eye Centre, Korle-Bu Teaching Hospital, Korle-Bu, Accra, Ghana.
Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad; Retina and Uveitis Department, GMR Varalakshmi Campus, LV Prasad Eye Institute, Hanumanthawaka Junction, Visakhapatnam, Andhra Pradesh, India.
出版信息
Indian J Ophthalmol. 2019 Jul;67(7):1109-1113. doi: 10.4103/ijo.IJO_1532_18.
PURPOSE
To compare the effectiveness of treatment with intravitreal bevacizumab (IVB) and ziv-aflibercept (IVZ) in patients with macular edema (ME) post-branch retinal vein occlusion (BRVO).
METHODS
Patients with treatment naïve ME post-BRVO were included retrospectively if they received either IVB (0.05 ml/1.25 mg) or IVZ (0.05 ml/1.25 mg) monotherapy with a follow up of 12 months.
RESULTS
Thirty-two and 17 eyes received IVB and IVZ, respectively. The mean improvement in best corrected visual acuity (BCVA) was 0.36 ± 0.3 logarithm of minimum angle of resolution (logMAR) in the IVB group and 0.27 ± 0.3 in the IVZ group (P = 0.35). The mean change in central macular thickness was 178.9 ± 180.9 and 173.5 ± 344.4 μm in IVB and IVZ groups, respectively (P = 0.94). The mean number of injections was higher in the IVB group (4.0 ± 1.8) compared with 1.82 ± 0.8 in the IVZ group (P < 0.0001). The IVZ group had significantly fewer number of visits (P < 0.0001) and longer maximum treatment-free intervals (P = 0.0081).
CONCLUSION
IVZ appears to be cost-effective with the similar visual outcome and less number of visits in comparison to IVB.
目的
比较玻璃体内注射贝伐单抗（IVB）和玻璃体内注射维替泊芬（IVZ）治疗视网膜分支静脉阻塞（BRVO）后黄斑水肿（ME）的疗效。
方法
回顾性纳入治疗初发 BRVO 后 ME 且接受 IVB（0.05ml/1.25mg）或 IVZ（0.05ml/1.25mg）单药治疗、随访时间 12 个月的患者。
结果
32 只眼和 17 只眼分别接受 IVB 和 IVZ 治疗。IVB 组最佳矫正视力（BCVA）平均提高 0.36±0.3 对数最小分辨角对数（logMAR），IVZ 组提高 0.27±0.3（P=0.35）。IVB 组中央黄斑厚度平均变化 178.9±180.9μm，IVZ 组 173.5±344.4μm（P=0.94）。IVB 组注射次数（4.0±1.8）高于 IVZ 组（1.82±0.8，P<0.0001）。IVZ 组就诊次数明显减少（P<0.0001），最长无治疗间隔时间延长（P=0.0081）。
结论
与 IVB 相比，IVZ 在视觉效果相似的情况下具有成本效益，且就诊次数更少。
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