Giros B, Llorens-Cortes C, Gros C, Schwartz J C
Unite 109 de Neurobiologie et Pharmacologie, Centre Paul Broca de l'INSERM, Paris, France.
NIDA Res Monogr. 1986;75:271-4.
The tripeptide Tyr-Gly-Gly (YGG) was established as an endogenous constituent in rat brain. Its origin from enkephalin neurons is suggested by its regional distribution paralleling that of (Met5)-enkephalin (YGGFM), its decrease following kainate-induced ablation of the striato-pallidal neurons and its enhanced formation following depolarization of pallidal slices. Enkephalinase (EC 3.4.24.11) is selectively responsible for endogenous YGG formation in vitro and in vivo.
三肽酪氨酸-甘氨酸-甘氨酸（YGG）被确定为大鼠脑中的一种内源性成分。其起源于脑啡肽神经元的推测依据如下：它的区域分布与（蛋氨酸5）-脑啡肽（YGGFM）的区域分布平行，在红藻氨酸诱导的纹状体苍白球神经元切除后其含量降低，以及在苍白球切片去极化后其生成增加。脑啡肽酶（EC 3.4.24.11）在体外和体内均选择性地负责内源性YGG的生成。
