Spada Fabrizio, Lui Ada H, Barnes Tanya M
Research & Development, Ego Pharmaceuticals, Braeside, Victoria 3195, Australia.
Clin Cosmet Investig Dermatol. 2019 Jun 6;12:415-425. doi: 10.2147/CCID.S212240. eCollection 2019.
Sensitive skin affects an increasingly large proportion of the population and is less tolerant to frequent and prolonged use of cosmetics. This study investigates the antiaging effects of a skin care system developed for use on sensitive skin. A total of 30 healthy Caucasian females, aged 32-72, were enrolled in this double-blind randomized placebo-controlled split-face study. A routine consisting of twice daily topical applications of the test cleanser and test moisturizer or placebo or positive control products was followed for 28 days, with parameters measured at baseline and at 7-day intervals. Objective skin assessments for hydration, transepidermal water loss (TEWL), skin surface topography, elasticity and safety assessment were conducted. Wrinkle surface, length and depth significantly improved by 34.8±4.7% (<0.001), 19.0±3.2% (<0.05) and 24.3±3.5% (<0.05), respectively, after 28 days of skin care treatment with the test cleanser and test moisturizer. R2 (gross elasticity), R5 (net elasticity) and R7 (biological elasticity) significantly increased by 32.8±6.5% (<0.001), 47.3±8.6% (<0.001) and 50.6±5.1% (<0.001), respectively, while R6 (viscoelastic portion) significantly decreased by 33.4±4.6% (<0.001) after 28 days. Skin hydration was also found to increase significantly after 28 days by 42.2±8.5% (<0.01), but there was no change in TEWL. No adverse events were reported. A novel skin care routine developed for use on sensitive skin significantly improves the signs of aging including hydration, wrinkle size and elasticity without significant adverse effects.
敏感性皮肤影响着越来越多的人群，且对频繁和长期使用化妆品的耐受性较低。本研究调查了一款专为敏感性皮肤开发的护肤系统的抗老化效果。共有30名年龄在32至72岁之间的健康白种女性参与了这项双盲随机安慰剂对照半脸研究。按照每日两次局部涂抹测试洁面产品和测试保湿产品或安慰剂或阳性对照产品的常规进行28天，在基线和每隔7天测量参数。进行了皮肤水合作用、经表皮水分流失（TEWL）、皮肤表面形貌、弹性和安全性评估等客观皮肤评估。在用测试洁面产品和测试保湿产品进行28天皮肤护理治疗后，皱纹表面、长度和深度分别显著改善了34.8±4.7%（<0.001）、19.0±3.2%（<0.05）和24.3±3.5%（<0.05）。28天后，R2（总弹性）、R5（净弹性）和R7（生物弹性）分别显著增加了32.8±6.5%（<0.001）、47.3±8.6%（<0.001）和50.6±5.1%（<0.001），而R6（粘弹性部分）显著下降了33.4±4.6%（<0.001）。28天后还发现皮肤水合作用显著增加了42.2±8.5%（<0.01），但TEWL没有变化。未报告不良事件。一款专为敏感性皮肤开发的新型护肤常规显著改善了包括水合作用、皱纹大小和弹性在内的老化迹象，且无显著不良影响。
