Valdis Matthew, Thain Andrew, Jones Philip M, Chan Ian, Chu Michael W A
Division of Cardiac Surgery, Department of Surgery, Western University, London Health Sciences Centre, London, Ontario, Canada.
Division of Cardiology, Department of Medicine, Western University, London Health Sciences Centre, London, Ontario, Canada.
Ann Cardiothorac Surg. 2019 May;8(3):362-371. doi: 10.21037/acs.2019.05.09.
Controversy exists regarding the optimal annular stabilization technique following valve sparing aortic root reconstruction (VSRR) with no comprehensive imaging data to evaluate the natural history of aortic root graft geometry, aortic valve competency and patient prognosis post-reconstruction.
Between 2008-2017, 70 consecutive patients (mean age 56.4±16.4 years, 19.7% females) underwent VSRR. All patients were prospectively evaluated annually with clinical follow-up, echocardiography and CT imaging. Patients were assessed for survival, freedom from reoperation, degree of regurgitation, New York Heart Association (NYHA) status and graft complications and followed up to nine years post-operatively (mean 36±21 months).
The largest increase of the aortic annulus diameter observed during the surveillance period was 2.64%±5.4% which occurred between the second and third years of follow-up and the aortic sinuses, sinotubular junction and ascending aorta all remained relatively stable based on annual CT imaging. Echocardiographic data showed far more variability in measurements at each annual post-operative visit with far less precision compared to the CT measurements taken at the same time. Due to the large variability and greater standard deviations, no significant difference was detected between the more precise CT measurements and those from the echocardiogram images. The overall survival rate was 94.3% (66 patients) at one year. Freedom from reoperation was 98.6% (69 patients). Throughout the entire duration of follow-up, aortic insufficiency was identified as 0 in 46 (65.7%), 1+ in 19 (27.1%), 2+ in 4 (5.7%), 3+ in 0 (0%) and 4+ in 1 (1.4%). Mean NYHA status was 1.1±0.3 at most recent follow-up for all patients. CT evidence showed 97.0% (64 patients) freedom from graft complication including: endocarditis, thrombosis, embolism, aneurysm, pseudoaneurysm, dehiscence, dissection and kinking.
The annual imaging data presented here demonstrates stability of the Dacron aortic annuloplasty reconstruction over time, without the need for internal or external annular stabilization. CT imaging proved to be far more reliable than echocardiographic images, however given the stability, annual CT imaging is of little benefit. This is the first prospective study to compare echocardiographic, CT and clinical data following VSRR.
在保留瓣膜的主动脉根部重建术(VSRR)后,关于最佳的主动脉环稳定技术存在争议,目前尚无全面的影像学数据来评估主动脉根部移植物几何形态、主动脉瓣功能及重建后患者预后的自然病程。
2008年至2017年期间,连续70例患者(平均年龄56.4±16.4岁,女性占19.7%)接受了VSRR。所有患者每年均接受前瞻性临床随访、超声心动图检查及CT成像评估。评估患者的生存率、再次手术的自由度、反流程度、纽约心脏协会(NYHA)心功能分级及移植物并发症情况,并随访至术后9年(平均36±21个月)。
在监测期内观察到的主动脉环直径最大增幅为2.64%±5.4%,发生在随访的第二年和第三年之间,基于年度CT成像,主动脉窦、窦管交界和升主动脉均保持相对稳定。超声心动图数据显示,与同期的CT测量相比,术后每年随访时测量值的变异性大得多,精度也低得多。由于变异性大且标准差更大,在更精确的CT测量值与超声心动图图像测量值之间未检测到显著差异。1年时的总生存率为94.3%(66例患者)。再次手术自由度为98.6%(69例患者)。在整个随访期间,46例(65.7%)患者的主动脉瓣关闭不全为0级,19例(27.1%)为1+级,4例(5.7%)为2+级,0例(0%)为3+级,1例(1.4%)为4+级。所有患者在最近一次随访时的平均NYHA心功能分级为1.1±0.3。CT证据显示97.0%(64例患者)无移植物并发症,包括:心内膜炎、血栓形成、栓塞、动脉瘤、假性动脉瘤裂开、夹层和扭结。
本文提供的年度影像学数据表明,随着时间推移,涤纶主动脉环成形术重建具有稳定性,无需进行内部或外部主动脉环稳定。CT成像被证明比超声心动图图像可靠得多,然而鉴于其稳定性,年度CT成像益处不大。这是第一项比较VSRR术后超声心动图、CT和临床数据的前瞻性研究。