Department of Neonatology, Children's Hospital, University of Tübingen, Tübingen, Germany.
ARCIM-Institute, Filderstadt, Germany.
Acta Paediatr. 2019 Dec;108(12):2246-2252. doi: 10.1111/apa.14914. Epub 2019 Aug 8.
Oximetry values are influenced by the averaging time (AT) used. We aimed to evaluate the effect of different ATs on number, duration, mean single event and total integral of desaturations in preterm infants and children to convert between parameters obtained with different ATs.
In a prospective observational study, 49 children underwent sleep laboratory-based polysomnography and 15 preterm infants were studied in the intensive care unit. Their raw red-to-infrared-saturation-data were reprocessed using seven different ATs (3-16 seconds). Desaturation thresholds were <80% (infants) and <90% (children), conversion formulas and their median percentage errors were calculated.
We found a linear relationship between the logarithms of the ATs and those of the desaturation parameters, leading to a conversion formula with different exponents. Based on this relationship, the number of desaturations decreased from AT = 3s to AT = 16s by factor 0.28 (children) and 0.18 (infants); total oxygen saturation integral decreased by factor 0.72 (children) and 0.48 (infants). The desaturation duration increased by factor 1.89 (children) and 3.34 (infants).
The number and total integral decreased, but the duration and mean single event integral increased with increasing AT. These changes were stronger in infants. Conversion formulas may facilitate comparisons between studies using different averaging times.
血氧饱和度值受平均时间(AT)的影响。我们旨在评估不同 AT 对早产儿和儿童中脱氧次数、持续时间、单个事件平均和总积分的影响,以便在使用不同 AT 获得的参数之间进行转换。
在一项前瞻性观察研究中,49 名儿童接受了睡眠实验室多导睡眠图检查,15 名早产儿在重症监护病房接受了研究。他们的原始红-红外线饱和度数据使用七种不同的 AT(3-16 秒)进行重新处理。脱氧阈值为<80%(婴儿)和<90%(儿童),计算了转换公式及其中位数百分比误差。
我们发现 AT 和脱氧参数的对数之间存在线性关系,导致转换公式具有不同的指数。基于这种关系,从 AT=3s 到 AT=16s,脱氧次数减少了 0.28(儿童)和 0.18(婴儿);总氧饱和度积分减少了 0.72(儿童)和 0.48(婴儿)。脱氧持续时间增加了 1.89(儿童)和 3.34(婴儿)。
随着 AT 的增加,数量和总积分减少,但持续时间和单个事件平均积分增加。这些变化在婴儿中更为明显。转换公式可以方便在使用不同平均时间的研究之间进行比较。