Kannan Loganathan Prakash, Nettel-Aguirre Alberto, Lodha Abhay, Al Awad Essa, Fajardo Carlos, Nair Vrinda, Scotland Jeanne, Singhal Nalini, Young Marilyn, York Kristin, Rabi Yacov
Neonatal Intensive Care Unit, The James Cook University Hospital, Middlesbrough, UK.
Clinical Academic Office, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Paediatr Child Health. 2023 Nov 24;29(7):422-428. doi: 10.1093/pch/pxad072. eCollection 2024 Nov.
To determine oxygen saturation (SpO) values and their variability in healthy-term neonates at high altitude.
In a prospective multisite, non-randomized blinded study, we performed SpO measurements in healthy neonates admitted to postnatal wards and followed up in Public Health Nurse Clinics (PHNC) in Calgary, Alberta, Canada. We recruited healthy-term neonates (≥37 weeks) between 6 and 24 h of age. Neonates underwent simultaneous pre- and post-ductal SpO recordings every 12 to 24 h until hospital discharge and again in the PHNC within a few days after discharge. Neonates were followed for 8 weeks to ascertain their health status.
We included data for 252 neonates in hospital and 105 neonates presenting to the PHNC for follow-up. In hospital, the mean pre- and post-ductal SpO were 94.3% and 96.0%, respectively. In the PHNC, mean pre- and post-ductal SpO were 94.4% and 95.6%, respectively. Desaturation episodes occurred frequently at a median rate of once every 5 minutes. The median duration of pre-ductal desaturation episodes was longer in hospital than in the PHNC for all SpO thresholds (P < 0.05).
SpO levels in healthy-term neonates at high altitude are approximately 94% and remained stable over the first few days after birth. Desaturation episodes are common in the immediate neonatal period, but their duration decreases over time, and they are not associated with clinical deterioration.Clinic trials.org (NCT02095041).
确定健康足月儿在高海拔地区的血氧饱和度（SpO）值及其变异性。
在一项前瞻性多中心、非随机双盲研究中，我们对入住加拿大艾伯塔省卡尔加里市产后病房并在公共卫生护士诊所（PHNC）接受随访的健康新生儿进行了SpO测量。我们招募了出生6至24小时的健康足月儿（≥37周）。新生儿在出生后每12至24小时进行一次同时的导管前和导管后SpO记录，直至出院，出院后几天内在PHNC再次进行记录。对新生儿进行8周的随访以确定其健康状况。
我们纳入了252名住院新生儿和105名到PHNC进行随访的新生儿的数据。在医院，导管前和导管后SpO的平均值分别为94.3%和96.0%。在PHNC，导管前和导管后SpO的平均值分别为94.4%和95.6%。血氧饱和度下降事件频繁发生，中位发生率为每5分钟一次。对于所有SpO阈值，医院中导管前血氧饱和度下降事件的中位持续时间均长于PHNC（P<0.05）。
高海拔地区健康足月儿的SpO水平约为94%，且在出生后的头几天保持稳定。血氧饱和度下降事件在新生儿早期很常见，但其持续时间会随着时间而缩短，且与临床病情恶化无关。Clinicaltrials.org（NCT02095041）。
