合成人精浆α-抑制素-92在体内选择性抑制促卵泡激素释放。
Synthetic human seminal alpha-inhibin-92 selectively suppresses follicle-stimulating hormone release in vivo.
作者信息
Yu W H, McCann S M, Li C H
机构信息
University of Texas Health Science Center, Department of Physiology, Dallas 75235.
出版信息
Proc Natl Acad Sci U S A. 1988 Jan;85(1):289-92. doi: 10.1073/pnas.85.1.289.
A 92-amino acid polypeptide, alpha-inhibin-92 (alpha-IB-92), has been isolated and characterized from human seminal plasma and found to be active in suppressing follicle-stimulating hormone (FSH) release in vitro. In the present in vivo study, intravenous injection of synthetic alpha-IB-92 (4 and 20 micrograms) significantly suppressed FSH release (P less than 0.001), whereas this peptide had no effect on luteinizing hormone (LH) release in 1-day orchidectomized male rats. In contrast, third ventricular injection of alpha-IB-92 (0.02, 0.4, 4, or 20 micrograms) had no effect on FSH and LH release in 1- or 2-day orchidectomized rats. These results indicate that alpha-IB-92 exerts a FSH suppressing activity by direct action on the pituitary gland.
一种由92个氨基酸组成的多肽，α-抑制素-92（α-IB-92），已从人精浆中分离并鉴定出来，且发现它在体外具有抑制促卵泡激素（FSH）释放的活性。在目前的体内研究中，静脉注射合成的α-IB-92（4微克和20微克）可显著抑制FSH释放（P<0.001），而该肽对1天去势雄性大鼠的促黄体生成素（LH）释放没有影响。相比之下，向第三脑室注射α-IB-92（0.02微克、0.4微克、4微克或20微克）对1天或2天去势大鼠的FSH和LH释放没有影响。这些结果表明，α-IB-92通过直接作用于垂体发挥FSH抑制活性。
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