Karmali R A
Department of Nutrition, Rutgers State University of New Jersey, New Brunswick 08903.
Prostaglandins Leukot Med. 1987 Oct;29(2-3):175-9. doi: 10.1016/0262-1746(87)90006-0.
Oral administration of two nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, can suppress the Salmonella-induced arthritis in rats. The joint swelling index of arthritic paws showed suppression of arthritis in animals treated with the drugs, this effect being greater with flurbiprofen. Measurement of 5 eicosanoids in femoral vein plasma showed increase of arachidonic acid products in Salmonella-treated rats. Inhibition of joint inflammation resulting from treatment with ibuprofen and flurbiprofen is reflected by a decrease in concentration of all 5 eicosanoids which were found in the order: PGE2 greater than TXB2 greater than 6-keto-PGF1 alpha greater than PGF1 greater than PGF2 alpha. These studies indicate that flurbiprofen is a more powerful anti-inflammatory agent than ibuprofen. However, since the joint disease was not completely cured, optimal intervention is quite likely to require modulation of the lipoxygenase pathway.
口服两种非甾体抗炎药布洛芬和氟比洛芬，可抑制大鼠沙门氏菌诱导的关节炎。关节炎爪子的关节肿胀指数显示，用药治疗的动物关节炎得到抑制，氟比洛芬的这种作用更强。股静脉血浆中5种类花生酸的测定表明，经沙门氏菌处理的大鼠花生四烯酸产物增加。布洛芬和氟比洛芬治疗导致的关节炎症抑制表现为所有5种类花生酸浓度降低，其顺序为：前列腺素E2＞血栓素B2＞6-酮-前列腺素F1α＞前列腺素F1＞前列腺素F2α。这些研究表明，氟比洛芬是比布洛芬更强效的抗炎剂。然而，由于关节疾病未完全治愈，最佳干预措施很可能需要调节脂氧合酶途径。
