Jarrett J C, Dawood M Y
Am J Obstet Gynecol. 1986 Dec;155(6):1186-92. doi: 10.1016/0002-9378(86)90142-0.
To determine if the prostaglandin synthetase inhibitors ibuprofen and flurbiprofen can suppress postoperative adhesion formation, New Zealand White rabbits that had uterine tubal ligation underwent uterine tube reanastomosis and were given either saline solution (controls), 75 mg of ibuprofen intravenously every 6 hours, or 12.5 mg of flurbiprofen intravenously every 6 hours for 8 doses after operation. Both ibuprofen and flurbiprofen significantly reduced postoperative adhesions (p less than 0.025). With histologic indices of tissue reunion, ibuprofen and flurbiprofen were associated with significantly less scar thickness than controls (p less than 0.001) but did not have any significant effect on mucosal regeneration, foreign body reaction, and muscularis disruption. When all four histologic indices were compared, flurbiprofen but not ibuprofen had a significantly lower score than controls, indicating the greater potency of flurbiprofen over ibuprofen. Our findings show that ibuprofen and flurbiprofen can suppress perioperative and postoperative surgically induced inflammatory response associated with healing and thereby reduce adhesion formation and scar thickness.
为了确定前列腺素合成酶抑制剂布洛芬和氟比洛芬是否能够抑制术后粘连形成，对接受子宫输卵管结扎术的新西兰白兔进行输卵管再吻合术，并在术后给予生理盐水（对照组）、每6小时静脉注射75毫克布洛芬或每6小时静脉注射12.5毫克氟比洛芬，共8剂。布洛芬和氟比洛芬均显著减少了术后粘连（p<0.025）。根据组织愈合的组织学指标，布洛芬和氟比洛芬组的瘢痕厚度显著低于对照组（p<0.001），但对黏膜再生、异物反应和肌层破坏没有任何显著影响。当比较所有四项组织学指标时，氟比洛芬组的得分显著低于对照组，而布洛芬组则不然，这表明氟比洛芬比布洛芬的效力更强。我们的研究结果表明，布洛芬和氟比洛芬能够抑制围手术期和术后与愈合相关的手术诱发的炎症反应，从而减少粘连形成和瘢痕厚度。
