Department of Plant Sciences, University of California, Davis, CA.
Phytopathology. 2019 Nov;109(11):1878-1887. doi: 10.1094/PHYTO-04-19-0115-R. Epub 2019 Oct 1.
Root parasitic weeds in Orobanchaceae pose a tremendous threat to agriculture worldwide. We used an in vitro assay to screen libraries of small molecules for those capable of inhibiting or enhancing haustorium development in the parasitic plant . Several redox-modifying molecules and one structural analog of 2,6-dimethoxybenzoquine (DMBQ) inhibited haustorium development in the presence of the haustorium-inducing factor DMBQ, some of these without apparent growth inhibition to the root. seedlings were able to acclimate to some of these redox inhibitors. Transcript levels of four early-stage haustorium genes were differentially influenced by inhibitors. These novel haustorium inhibitors highlight the importance of redox cycling for haustorium development and suggest the potential of controlling parasitic weeds by interrupting early-stage redox-signaling pathways.
列当科根寄生杂草对全球农业构成了巨大威胁。我们使用体外测定法筛选小分子文库，以寻找能够抑制或增强寄生植物吸器发育的小分子。几种氧化还原修饰分子和一种 2,6-二甲氧基苯醌（DMBQ）的结构类似物在吸器诱导因子 DMBQ 的存在下抑制吸器发育，其中一些对根的生长没有明显抑制作用。幼苗能够适应其中一些氧化还原抑制剂。四个早期吸器基因的转录水平受抑制剂的差异影响。这些新型吸器抑制剂强调了氧化还原循环对吸器发育的重要性，并表明通过中断早期氧化还原信号通路来控制寄生杂草的潜力。
