Gobato Amanda Oliva, Vasques Ana Carolina Junqueira, Ribeiro Antonio Fernando, Yamada Roberto Massao, Hessel Gabriel
Universidade Estadual de Campinas, Campinas, SP, Brazil.
Rev Paul Pediatr. 2019 Jun 19;37(4):435-441. doi: 10.1590/1984-0462/;2019;37;4;00007. eCollection 2019.
To determine the prevalence of hepatic steatosis (HS) in children and adolescents with cystic fibrosis (CF) and associate it with nutritional status.
Cross-sectional study with children and adolescents with CF diagnosis. Weight and height were used to calculate the body mass index (BMI) and subsequent classification of the nutritional status. The midarm circumference (MAC), triceps skinfold thickness (TSF) and midarm muscle circumference (MAMC) were used to evaluate body composition. Abdominal ultrasonography was performed for diagnosis of HS. The statistical tests used were Student's t test, Mann-Whitney test and chi-square test with significance level of 5%.
50 patients with CF were evaluated, 18 (36%) were diagnosed with HS (Group A) and 32 (64%) without HS (Group B). The mean age of Group A was 13,2±4,9 years old and Group B 11,7±4,9; for BMI, the value for Group A was 18,0±4,1 and Group B was 15,7±3,8; the TSF of Group A was 8,4±3,5 mm and Group B was 7,0±2,5 mm. For these variables, there was no significant difference between the groups. The mean of MAC and MAMC differed significantly between the groups, being higher in the HS group, with p values of 0,047 and 0,043.
The frequency of HS in patients with CF is high and it is not related to malnutrition, according to the parameters of BMI, TSF and MAMC. The values of MAC and MAMC indicated a greater reserve of muscle mass in patients with HS.
确定囊性纤维化（CF）儿童和青少年肝脂肪变性（HS）的患病率，并将其与营养状况相关联。
对确诊为CF的儿童和青少年进行横断面研究。使用体重和身高计算体重指数（BMI），并随后对营养状况进行分类。使用上臂围（MAC）、肱三头肌皮褶厚度（TSF）和上臂肌肉围（MAMC）来评估身体成分。进行腹部超声检查以诊断HS。所使用的统计检验为Student's t检验、Mann-Whitney检验和卡方检验，显著性水平为5%。
对50例CF患者进行了评估，18例（36%）被诊断为HS（A组），32例（64%）未患HS（B组）。A组的平均年龄为13.2±4.9岁，B组为11.7±4.9岁；对于BMI，A组的值为18.0±4.1，B组为15.7±3.8；A组的TSF为8.4±3.5mm，B组为7.0±2.5mm。对于这些变量，两组之间无显著差异。两组之间MAC和MAMC的平均值差异显著，HS组更高，p值分别为0.047和0.043。
根据BMI、TSF和MAMC参数，CF患者中HS的发生率较高，且与营养不良无关。MAC和MAMC的值表明HS患者的肌肉量储备更大。
