Longoni R, Spina L, Di Chiara G
Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Italy.
Psychopharmacology (Berl). 1987;93(3):401-2. doi: 10.1007/BF00187265.
Administration of morphine HCl (20 mg/kg SC) to male C57Bl/6 mice evoked hypermotility. Pretreatment with low doses of the specific D-1 antagonist SCH 23390 (0.006, 0.012, 0.025 mg/kg SC) dose-dependently inhibited morphine-evoked hypermotility. The results suggest that dopamine is the essential mediator of opiate hypermotility and indicate that D-1 receptors play an important role in this effect.
给雄性C57Bl/6小鼠皮下注射盐酸吗啡（20毫克/千克）会引起运动亢进。用低剂量的特异性D-1拮抗剂SCH 23390（0.006、0.012、0.025毫克/千克，皮下注射）进行预处理，可剂量依赖性地抑制吗啡引起的运动亢进。结果表明，多巴胺是阿片类药物引起运动亢进的重要介质，并且表明D-1受体在这种作用中起重要作用。
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