法国监狱囚犯中戊型肝炎病毒的流行情况以及对 HIV 和其他肝炎病毒血清流行率的重新评估。

Prevalence of hepatitis E virus and reassessment of HIV and other hepatitis virus seroprevalences among French prison inmates.

机构信息

Virologie, Hôpital Paul Brousse, AP-HP, Villejuif, France.

INSERM U1193, Villejuif, France.

出版信息

PLoS One. 2019 Jun 26;14(6):e0218482. doi: 10.1371/journal.pone.0218482. eCollection 2019.

DOI:10.1371/journal.pone.0218482

PMID:31242210

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6594613/

Abstract

BACKGROUND

Prison inmates are considered a high-risk population for blood-borne and enterically transmitted infections before and during their imprisonment. Hepatitis E virus (HEV) prevalence is unknown among French inmates, whereas a reassessment of human immunodeficiency virus (HIV), hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) prevalences is required to describe the epidemiologic evolution in this high-risk population.

METHODS

A prospective survey was conducted from June to December 2017 in Fresnes prison, a penitentiary center with 2,581 inmates. In addition to HIV, HAV, HBV and HCV testing, which is offered to all patients at admission, we systematically offered HEV screening. Retrospective serological data for HIV, HBV and HCV, collected annually from 2014 to 2017, were also used to assess evolution.

RESULTS

In 2017, 1,093 inmates were screened for HEV, HIV, HAV, HBV and HCV. Prevalences in this population were 8.2%, 1.3%, 62.7%, 1.9% and 2.9%, respectively. HEV seroprevalence increased with age (p<0.0001) and was higher among Eastern Europe born inmates (p<0.0001). Between 2014 and 2017, HIV seroprevalence remained steady, while a decrease in HBV and HCV seroprevalence was observed.

CONCLUSIONS

Compared to the reported prevalence in French blood donors, HEV seroprevalence was remarkably low in French inmates. HIV, HAV, HBV and HCV prevalences among prisoners were higher than reported in the general population.

摘要

背景

在入狱前和入狱期间，囚犯被认为是血液传播和肠道传播感染的高风险人群。在法国囚犯中，戊型肝炎病毒（HEV）的流行情况尚不清楚，而需要重新评估人类免疫缺陷病毒（HIV）、甲型肝炎病毒（HAV）、乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）的流行情况，以描述该高风险人群中的流行病学演变。

方法

2017 年 6 月至 12 月，在 Fresnes 监狱进行了一项前瞻性调查，该监狱是一个拥有 2581 名囚犯的监狱中心。除了为所有入院患者提供的 HIV、HAV、HBV 和 HCV 检测外，我们还系统地提供了 HEV 筛查。还使用了 2014 年至 2017 年每年收集的 HIV、HBV 和 HCV 的回顾性血清学数据来评估演变。

结果

2017 年，有 1093 名囚犯接受了 HEV、HIV、HAV、HBV 和 HCV 的筛查。该人群中的流行率分别为 8.2%、1.3%、62.7%、1.9%和 2.9%。HEV 血清阳性率随年龄增长而增加（p<0.0001），并且在东欧出生的囚犯中更高（p<0.0001）。2014 年至 2017 年间，HIV 血清阳性率保持稳定，而 HBV 和 HCV 血清阳性率下降。