Institute of Physiology, Christian-Albrechts-University Kiel, 24098 Kiel, Germany.
Institute of Physiology, Christian-Albrechts-University Kiel, 24098 Kiel, Germany.
Cell Rep. 2019 Jun 25;27(13):3725-3732.e5. doi: 10.1016/j.celrep.2019.05.098.
Dendritic spines control synaptic transmission and plasticity by augmenting post-synaptic potentials and providing biochemical compartmentalization. In principal cells, spines cover the dendritic tree at high densities, receive the overwhelming majority of excitatory inputs, and undergo experience-dependent structural re-organization. Although GABAergic interneurons have long been considered to be devoid of spines, a number of studies have reported the sparse existence of spines in interneurons. However, little is known about their organization or function at the cellular and network level. Here, we show that a subset of hippocampal parvalbumin-positive interneurons forms numerous dendritic spines with highly variable densities and input-selective organization. These spines form in areas with reduced perineuronal net sheathing, predispose for plastic changes in protein expression, and show input-specific re-organization after behavioral experience.
树突棘通过增强突触后电位和提供生化分隔来控制突触传递和可塑性。在主细胞中，棘突以高密度覆盖树突，接收绝大多数兴奋性输入，并经历经验依赖性的结构重组。尽管 GABA 能中间神经元长期以来被认为没有棘突，但有一些研究报告了中间神经元中棘突的稀疏存在。然而，关于它们在细胞和网络水平上的组织或功能知之甚少。在这里，我们表明，海马 CA1 区的一部分小清蛋白阳性中间神经元形成了许多具有高度可变密度和输入选择性组织的树突棘。这些棘突形成于少层神经毡包绕的区域，易于发生蛋白质表达的可塑性变化，并在行为经验后表现出输入特异性的重组。
