Mutlu Mehmet, Aslan Yakup, Kader Şebnem, Aktürk Acar Filiz
Department of Neonatology, Karadeniz Technical University, Trabzon, Turkey.
Am J Perinatol. 2020 Sep;37(11):1173-1176. doi: 10.1055/s-0039-1692690. Epub 2019 Jun 26.
Probiotic supplementation can help to improve recovery from jaundice by reducing enterohepatic circulation through the regulation of intestinal microbial flora. The aim of our study was to investigate the effect of probiotic supplementation on neonatal hyperbilirubinemia caused by isoimmunization alone.
Sixty neonates were randomly divided into a placebo group and a probiotic group ( GG). Serum total bilirubin (STB) levels were measured at birth and at 4, 8, 16, 24, and 36 hours of treatment (and at 48, 60, and 72 hours if necessary). Duration of phototherapy, rephototherapy requirements, and daily meconium evacuation were recorded.
STB and rebound STB levels at 36 hours were lower in the probiotic group than in the placebo group ( = 0.01 and = 0.006, respectively). Meconium evacuation was more frequent in the probiotic group than in the placebo group on the second and third days of life ( = 0.002 and 0.009, respectively).
Probiotics do not affect STB levels in the first 24 hours of life or duration of phototherapy in neonates with jaundice caused by blood group incompatibility. The effect of probiotic supplementation by reducing enterohepatic circulation occurs at 36 hours of life in newborns with isoimmunization.
补充益生菌可通过调节肠道微生物群减少肠肝循环，从而有助于改善黄疸的恢复。我们研究的目的是调查单独补充益生菌对由血型不合引起的新生儿高胆红素血症的影响。
60例新生儿被随机分为安慰剂组和益生菌组（GG）。在出生时以及治疗后4、8、16、24和36小时（必要时在48、60和72小时）测量血清总胆红素（STB）水平。记录光疗持续时间、再次光疗需求和每日胎粪排出情况。
益生菌组36小时时的STB和反弹STB水平低于安慰剂组（分别为P = 0.01和P = 0.006）。在生命的第二天和第三天，益生菌组的胎粪排出比安慰剂组更频繁（分别为P = 0.002和P = 0.009）。
对于由血型不合引起黄疸的新生儿，益生菌在生命的最初24小时内不影响STB水平或光疗持续时间。在血型不合的新生儿中，补充益生菌通过减少肠肝循环的作用在生命36小时时出现。
