Chen J Y, Ling U P, Chen J H
Department of Pediatrics, Chung Shan Medical and Dental College Hospital, Taichung, Taiwan, Republic of China.
Am J Perinatol. 1995 Jul;12(4):232-4. doi: 10.1055/s-2007-994460.
Delayed passage of meconium may increase enterohepatic circulation of bilirubin, which appears to be an important contributor to neonatal jaundice. To evaluate the effect of early meconium evacuation on neonatal hyperbilirubinemia, between January 1993 and December 1993, 265 healthy neonates were studied and randomly divided into two groups. Group 1 consisted of 130 neonates who received glycerin enema (1 mL of glycerin mixed with 1 mL of warmed normal saline) within 30 minutes after birth and the same procedure was repeated at 12 hours of age. Group 2 consisted of 135 neonates receiving no glycerin enema throughout their hospital stay. Determination of total serum bilirubin using capillary samples was performed daily for 7 days. Our data showed that 12 neonates (15.4%) in group 1 and 18 neonates (13.3%) in group 2 had serum bilirubin level 15 mg/dL or higher and received phototherapy. We conclude that early evacuation of meconium by using glycerin enema within 30 minutes after birth and 12 hours after birth in order to reduce enterohepatic circulation of bilirubin has no effect on lowering peak serum bilirubin levels or on serum bilirubin concentrations in the first 7 days of life.
胎粪排出延迟可能会增加胆红素的肠肝循环，这似乎是新生儿黄疸的一个重要原因。为了评估早期排出胎粪对新生儿高胆红素血症的影响，在1993年1月至1993年12月期间，对265名健康新生儿进行了研究，并随机分为两组。第一组由130名新生儿组成，他们在出生后30分钟内接受甘油灌肠（1毫升甘油与1毫升温热生理盐水混合），并在12小时时重复相同操作。第二组由135名新生儿组成，他们在住院期间未接受甘油灌肠。连续7天每天使用毛细血管样本测定血清总胆红素。我们的数据显示，第一组中有12名新生儿（15.4%），第二组中有18名新生儿（13.3%）血清胆红素水平达到或高于15mg/dL并接受了光疗。我们得出结论，在出生后30分钟内和出生后12小时使用甘油灌肠以减少胆红素的肠肝循环，对降低出生后7天内的血清胆红素峰值水平或血清胆红素浓度没有影响。
