a Department of Drugs and Medicines , São Paulo State University-UNESP , Araraquara , Brazil.
b Department of Organic Chemistry , São Paulo State University-UNESP , Araraquara , Brazil.
Nat Prod Res. 2019 Sep;33(17):2579-2582. doi: 10.1080/14786419.2018.1460827. Epub 2018 Apr 5.
is a plant species with edible fruits but its chemical composition is not totally known yet although former studies showed its potential as antifungal agent. This work aimed the chemical analysis of the leaves, the activity against fungi species and evaluated cytotoxicity. Extract was obtained with 70% ethanol. An ethyl acetate fraction was obtained and glycosylated quercetin and myricetin were isolated. Samples were tested against species, dermatophytes and entomopathogenic fungi. Cytotoxicity was evaluated against fibroblast cells. Extract showed good activity against (minimum inhibitory concentration at 156 μg/mL), (78 μg/mL), (19 μg/mL) (78 μg/mL) and (156 μg/mL). Isolated compounds were more active against and . The extract, which was the more active sample, demonstrated low cytotoxic effect and encourage more studies against rising non- species and dermatophyte .
是一种具有可食用果实的植物物种,但它的化学成分尚未完全了解,尽管以前的研究表明它具有抗真菌剂的潜力。这项工作旨在对叶片进行化学分析,研究其对真菌物种的活性,并评估细胞毒性。使用 70%乙醇提取。得到了乙酸乙酯部分,并分离出了糖苷化的槲皮素和杨梅素。样品针对 种、皮肤真菌和昆虫病原真菌进行了测试。对成纤维细胞进行了细胞毒性评估。提取物对 (最低抑菌浓度为 156μg/mL)、 (78μg/mL)、 (19μg/mL)(78μg/mL)和 (156μg/mL)具有良好的活性。分离出的化合物对 和 更具活性。提取物是最具活性的样品,显示出低细胞毒性作用,并鼓励对不断增加的非 种和皮肤真菌进行更多研究。