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界定腹膜透析在充血性心力衰竭管理中的作用。

Defining the role of peritoneal dialysis in management of congestive heart failure.

作者信息

Kazory Amir, Bargman Joanne M

机构信息

a Division of Nephrology, Hypertension, and Renal Transplantation , University of Florida , Gainesville , FL , USA.

b Division of Nephrology , University Health Network , Toronto , Ontario , Canada.

出版信息

Expert Rev Cardiovasc Ther. 2019 Jul;17(7):533-543. doi: 10.1080/14779072.2019.1637254. Epub 2019 Jul 2.

Abstract

: Congestion is an integral component of heart failure (HF) pathophysiology and portends an adverse impact on outcome. Peritoneal dialysis (PD) is a home-based therapeutic modality that has been used in the setting of refractory congestive HF to help optimize volume status. Not only does PD allow for customized sodium and water removal, but it also provides the opportunity for the patients to fully benefit from guideline-directed medical therapy for HF that could have otherwise been challenging to use. : Authors provide an overview of the pathophysiologic basis for the use of PD in HF, followed by a review of the findings of the main clinical trials such as the salutary impact on HF re-admissions and quality of life. Since the goals of therapy in this setting differ from those for patients with end-stage renal disease, pertinent practical considerations in the use of this modality are then discussed as well as potential barriers. : For patients with chronic refractory HF, PD represents an alternative to medical therapy alone. Identification of patients that would benefit most from this modality and detection of major enablers and obstacles for the implementation of this therapy should be the focus of future studies.

摘要

充血是心力衰竭(HF)病理生理学的一个重要组成部分,预示着对预后有不利影响。腹膜透析(PD)是一种居家治疗方式,已用于难治性充血性心力衰竭的治疗,以帮助优化容量状态。PD不仅允许定制钠和水的清除,还为患者提供了充分受益于针对HF的指南指导药物治疗的机会,否则使用这些治疗可能具有挑战性。作者概述了在HF中使用PD的病理生理基础,随后回顾了主要临床试验的结果,如对HF再入院率和生活质量的有益影响。由于这种情况下的治疗目标与终末期肾病患者的治疗目标不同,因此还讨论了使用这种治疗方式的相关实际考虑因素以及潜在障碍。对于慢性难治性HF患者,PD是单独药物治疗的一种替代方法。识别最能从这种治疗方式中受益的患者以及检测实施这种治疗的主要促进因素和障碍应是未来研究的重点。

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