Kaya Başak, Turhan Uğur, Sezer Salim, Kaya Serdar, Dağ İsmail, Tayyar Ahmet
Department of Maternal-Fetal Medicine, İstanbul Medipol University Hospital, İstanbul, Turkey.
Department of Maternal-Fetal Medicine, Health Sciences University, Samsun Education and Research Hospital, Samsun, Turkey.
J Matern Fetal Neonatal Med. 2020 Mar;33(5):861-868. doi: 10.1080/14767058.2019.1637409. Epub 2019 Jul 7.
To investigate maternal serum galectin-1 and galectin-3 levels in pregnancies complicated with preterm prelabor rupture of membranes (PPROM) and to compare with pregnancies delivered at term. In this cross-sectional study, 40 women with singleton pregnancies complicated with PPROM between 24 and 34 weeks of gestation were compared with gestational age-matched 40 pregnant women with no obstetrics complications, who delivered at term. The maternal serum galectin-1 and galectin-3 levels were measured. Patients complicated with PPROM had significantly higher levels of galectin-1 ( = .001) and galectin-3 ( = .003) than the control group. Maternal serum galectin-3 levels were found significantly negatively correlated with the gestational age at delivery and birth weight. Maternal serum galectin-1 and galectin-3 levels were significantly higher in pregnancies complicated with PPROM. Galectin-1 and galectin-3, with their regulatory effects in key biological processes, may be both an initiating factor in the pathophysiology of PPROM, a marker in the prediction, and a target of preventing strategies of PPROM.
研究妊娠合并早产胎膜早破（PPROM）孕妇血清半乳糖凝集素-1和半乳糖凝集素-3水平，并与足月分娩孕妇进行比较。在这项横断面研究中，将40例妊娠24至34周单胎妊娠合并PPROM的妇女与40例孕周匹配、无产科并发症且足月分娩的孕妇进行比较。检测孕妇血清半乳糖凝集素-1和半乳糖凝集素-3水平。PPROM患者的半乳糖凝集素-1（P = 0.001）和半乳糖凝集素-3（P = 0.003）水平显著高于对照组。发现孕妇血清半乳糖凝集素-3水平与分娩孕周和出生体重呈显著负相关。妊娠合并PPROM时孕妇血清半乳糖凝集素-1和半乳糖凝集素-3水平显著升高。半乳糖凝集素-1和半乳糖凝集素-3在关键生物学过程中具有调节作用，可能既是PPROM病理生理学的起始因素，也是预测标志物以及PPROM预防策略的靶点。
