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Galectin-1 在胎儿生长受限孕妇血清和胎盘中的表达及其意义。

Galectin-1 expression in the serum and placenta of pregnant women with fetal growth restriction and its significance.

机构信息

Department of Reproductive Genetics, Women's Hospital of Zhejiang University, No. 1 of Xueshi Road, Shangcheng District, Hangzhou, 310006, China.

Department of Obstetrics, Taizhou Hospital, Zhejiang University, Taizhou, 317000, China.

出版信息

BMC Pregnancy Childbirth. 2021 Jan 6;21(1):14. doi: 10.1186/s12884-020-03477-8.

DOI:10.1186/s12884-020-03477-8
PMID:33407212
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7789211/
Abstract

BACKGROUND

This study aims to investigate galectin-1 (Gal-1) expression in the serum and placenta of pregnant women with fetal growth restriction (FGR) and its significance.

METHODS

Thirty-one pregnant women with single-birth FGR but without comorbidities, eight pregnant women with FGR and preeclampsia (PE), and eight pregnant women with FGR and gestational diabetes mellitus (GDM) were enrolled as the study group, while 20 pregnant women with normal singleton pregnancy in the same period were enrolled as the control group. The serum Gal-1 level was detected using an enzyme-linked immunosorbent assay (ELISA), and Gal-1 expression in the placenta was detected by western blot.

RESULTS

The results revealed that, compared with the control group, the serum Gal-1 level decreased in the women with FGR without comorbidities, and the difference was statistically significant (P < 0.001). Compared with the control group, the difference in serum Gal-1 expression in the FGR-PE group was not statistically significant (P = 0.29). The peripheral serum Gal-1 level decreased in the FGR-GDM group compared with the control group, and the difference was statistically significant (P < 0.001). The serum Gal-1 level was positively correlated with birth weight (r = 0.172, P < 0.01). Compared with the control group, the Gal-1 expression level decreased in the placenta of the pregnant women with FGR without comorbidities (P < 0.05).

CONCLUSIONS

Gal-1 exhibits low expression in the serum and placenta of pregnant women with FGR. In addition, Gal-1 may be involved in the pathogenesis of FGR and could represent a new diagnostic marker of the disease.

摘要

背景

本研究旨在探讨胎儿生长受限（FGR）孕妇血清和胎盘组织中半乳糖凝集素-1（Gal-1）的表达及其意义。

方法

选择单纯 FGR 且无合并症的孕妇 31 例（FGR 组）、FGR 合并子痫前期（PE）的孕妇 8 例（FGR-PE 组）和 FGR 合并妊娠期糖尿病（GDM）的孕妇 8 例（FGR-GDM 组）为观察组，同期选择正常单胎妊娠孕妇 20 例为对照组。采用酶联免疫吸附试验（ELISA）检测血清 Gal-1 水平，Western blot 检测胎盘组织 Gal-1 表达。

结果

与对照组相比，单纯 FGR 孕妇血清 Gal-1 水平降低，差异有统计学意义（P<0.001）；FGR-PE 组血清 Gal-1 表达与对照组比较差异无统计学意义（P=0.29）；FGR-GDM 组外周血清 Gal-1 水平低于对照组，差异有统计学意义（P<0.001）。血清 Gal-1 水平与出生体质量呈正相关（r=0.172，P<0.01）。与对照组相比，单纯 FGR 孕妇胎盘组织 Gal-1 表达水平降低（P<0.05）。

结论

Gal-1 在 FGR 孕妇血清和胎盘组织中呈低表达，Gal-1 可能参与 FGR 的发病机制，有望成为 FGR 的新型诊断标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02b/7789211/0ad8edeb9117/12884_2020_3477_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02b/7789211/172d9ad372ff/12884_2020_3477_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02b/7789211/26760406f9cf/12884_2020_3477_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02b/7789211/0ad8edeb9117/12884_2020_3477_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02b/7789211/172d9ad372ff/12884_2020_3477_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02b/7789211/26760406f9cf/12884_2020_3477_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e02b/7789211/0ad8edeb9117/12884_2020_3477_Fig3_HTML.jpg

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