Department of vascular surgery, xuanwu hospital, Capital medical unversity, Beijing, China.
Department of gastroesophageal reflux disease, The General Hospital of the PLA Rocket Force, Beijing, China.
BMC Gastroenterol. 2019 Jun 26;19(1):108. doi: 10.1186/s12876-019-1027-8.
The effect of laparoscopic fundoplication on reflux-related chronic cough is unpredictable, the aim of the study is to investigate the predictive effect of positive reflux-cough correlation on the resolution of reflux-related chronic cough after anti-reflux surgery.
A 5 years retrospective review was performed. Logistic regression analysis was used to determine the independent predictors on the cure of chronic cough.
Seventy-nine patients were included in this study, among which chronic cough was cured in 47 (59.5%) and significantly improved in 10 (12.7%) patients. Present of typical symptoms (odds ratio = 6.435,95% confidence interval [CI] = 1.427-29.032, p = 0.015) and number of Reflux episodes (impedance) ≥73 (odds ratio = 0.306, 95% confidence interval [CI] = 0.107-0.874, p = 0.027) were significantly associated with the cure of chronic cough.
laparoscopic fundoplicaiton is effective for the management of reflux-related chronic cough, particularly with the present of typical symptoms.
(Trial registration number: ChiCTR1800016444 ; Trial registration date: June 01, 2018).
腹腔镜胃底折叠术对反流相关性慢性咳嗽的疗效不可预测，本研究旨在探讨反流-咳嗽相关性阳性对反流相关性慢性咳嗽缓解的预测作用。
对 5 年的回顾性研究进行了分析。采用逻辑回归分析确定慢性咳嗽治愈的独立预测因子。
本研究共纳入 79 例患者，其中慢性咳嗽治愈 47 例（59.5%），明显改善 10 例（12.7%）。典型症状的存在（比值比=6.435，95%置信区间[CI]为 1.427-29.032，p=0.015）和反流次数（阻抗）≥73 次（比值比=0.306，95%置信区间[CI]为 0.107-0.874，p=0.027）与慢性咳嗽的治愈显著相关。
腹腔镜胃底折叠术是治疗反流相关性慢性咳嗽的有效方法，特别是对于存在典型症状的患者。
（试验注册号：ChiCTR1800016444；试验注册日期：2018 年 6 月 1 日）。
