大鼠单次给予邻苯二甲酸二（2-乙基己基）酯和邻苯二甲酸单（2-乙基己基）酯所致的睾丸毒性
Testicular toxicity induced by single dosing of di- and mono-(2-ethylhexyl) phthalate in the rat.
作者信息
Teirlynck O, Kaufman J M, Bogaert M G, Roels H
机构信息
Heymans Institute of Pharmacology, University of Ghent Medical School, Belgium.
出版信息
Toxicol Lett. 1988 Jan;40(1):85-91. doi: 10.1016/0378-4274(88)90186-5.
The testicular toxicity of di-(2-ethylhexyl) phthalate (DEHP), a widely used plasticizer, and of its major metabolite, mono-(2-ethylhexyl) phthalate (MEHP), was assessed after a single dose in rats. Treatment with a single dose of 2.8 g/kg DEHP or 0.8 g/kg MEHP was sufficient to induce testicular atrophy as observed 7 days after dosing. Such a treatment had no effect on plasma FSH levels, and had varying effects on testicular zinc concentrations. After a single dose of 0.8 g/kg MEHP the testicular toxicity was age-dependent, in that only prepubertal rats were susceptible.
邻苯二甲酸二（2-乙基己基）酯（DEHP）是一种广泛使用的增塑剂，对其主要代谢产物邻苯二甲酸单（2-乙基己基）酯（MEHP），在大鼠单次给药后评估了其睾丸毒性。单次给予2.8 g/kg DEHP或0.8 g/kg MEHP足以在给药7天后观察到睾丸萎缩。这种处理对血浆促卵泡激素（FSH）水平没有影响，对睾丸锌浓度有不同影响。单次给予0.8 g/kg MEHP后，睾丸毒性具有年龄依赖性，即只有青春期前大鼠易感。
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