邻苯二甲酸单（2-乙基己基）酯/邻苯二甲酸二（2-乙基己基）酯：性腺毒性及对啮齿动物附属生殖器官的影响
MEHP/DEHP: gonadal toxicity and effects on rodent accessory sex organs.
作者信息
Thomas J A, Curto K A, Thomas M J
出版信息
Environ Health Perspect. 1982 Nov;45:85-8. doi: 10.1289/ehp.824585.
Abstract
The phthalate acid esters (PAEs), and, in particular, di(2-ethylhexyl) phthalate (DEHP) and its monoester, monoethylhexyl phthalate (MEHP), can adversely affect rodent testes but only at high doses. Rat gonadal zinc levels can be decreased by the injection of DEHP, but not MEHP. The rat prostate gland seems to be particularly sensitive to PAE-induced zinc depletion. PAE-induced changes in male reproductive organs were more evident in the rat than in the mouse. Some of the effects of MEHP can be demonstrated in vitro since it can alter the uptake of 65Zn in rodent gonads and accessory sex organs.
摘要
邻苯二甲酸酯（PAEs），尤其是邻苯二甲酸二（2-乙基己基）酯（DEHP）及其单酯邻苯二甲酸单乙基己酯（MEHP），仅在高剂量时会对啮齿动物睾丸产生不利影响。注射DEHP可降低大鼠性腺锌水平，但MEHP不会。大鼠前列腺似乎对PAE诱导的锌耗竭特别敏感。PAE诱导的雄性生殖器官变化在大鼠中比在小鼠中更明显。MEHP的一些作用可以在体外得到证实，因为它可以改变啮齿动物性腺和附属生殖器官对65Zn的摄取。
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