Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, Germany.
Cardiovasc Res. 2019 Nov 1;115(13):1838-1849. doi: 10.1093/cvr/cvz161.
Heart disease is a major cause of death worldwide with increasing prevalence, which urges the development of new therapeutic strategies. Over the last few decades, numerous small animal models have been generated to mimic various pathomechanisms contributing to heart failure (HF). Despite some limitations, these animal models have greatly advanced our understanding of the pathogenesis of the different aetiologies of HF and paved the way to understanding the underlying mechanisms and development of successful treatments. These models utilize surgical techniques, genetic modifications, and pharmacological approaches. The present review discusses the strengths and limitations of commonly used small animal HF models, which continue to provide crucial insight and facilitate the development of new treatment strategies for patients with HF.
心脏病是全球范围内主要的死亡原因，其患病率不断上升，这促使人们开发新的治疗策略。在过去的几十年中，已经产生了许多小动物模型来模拟导致心力衰竭（HF）的各种病理机制。尽管存在一些局限性，但这些动物模型极大地促进了我们对 HF 不同病因发病机制的理解，并为理解潜在机制和成功治疗方法的发展铺平了道路。这些模型利用了手术技术、基因修饰和药理学方法。本文综述了常用于 HF 的小动物模型的优缺点，这些模型继续为 HF 患者提供重要的见解并促进新的治疗策略的发展。
