Department of Pharmacy, National University of Singapore, Singapore.
Programme in Health Services and Systems Research, Duke-NUS Medical School, Singapore.
Singapore Med J. 2019 Jun;60(6):270-280. doi: 10.11622/smedj.2019057.
This was a systematic review of the literature on the association between obesity and the outcome of inflammatory rheumatic diseases. We conducted a literature search using PubMed®, Embase and PsycINFO®. Articles were classified into three categories based on the effects of obesity on the outcomes of inflammatory rheumatic diseases. The subject population, country, type of studies, number of patients, measurement of obesity and outcomes assessed were presented. Quality was appraised using Kmet et al's criteria. 4,331 articles were screened and 60 were relevant to the objective. Obesity had a negative, positive and neutral association with outcomes of inflammatory rheumatic diseases in 38 (63.3%) studies with 57,612 subjects, 11 (18.3%) studies with 3,866 subjects, and 11 (18.3%) studies with 3,834 subjects, respectively. In most studies, the disease population had been diagnosed with rheumatoid arthritis (RA). Tumour necrosis factor-α inhibitors were mostly associated with negative outcomes. More studies examining subjects outside Europe and North America and diseases other than RA are warranted.
这是一篇关于肥胖与炎症性风湿病结局关系的文献系统综述。我们使用 PubMed®、Embase 和 PsycINFO®进行了文献检索。根据肥胖对炎症性风湿病结局的影响，将文章分为三类。呈现了研究对象人群、国家、研究类型、患者数量、肥胖的测量方法和评估的结局。使用 Kmet 等人的标准对质量进行了评估。共筛选出 4331 篇文章，其中 60 篇与目标相关。在 57612 名受试者的 38 项（63.3%）研究中、3834 名受试者的 11 项（18.3%）研究中、3866 名受试者的 11 项（18.3%）研究中，肥胖与炎症性风湿病结局呈负相关、正相关和中性相关。在大多数研究中，疾病人群被诊断为类风湿关节炎（RA）。肿瘤坏死因子-α 抑制剂大多与不良结局相关。需要更多研究检查欧洲和北美以外的人群以及除 RA 以外的疾病。
