Asian Demographic Research Institute, Shanghai University, Shanghai, China.
Department of Health Policy and Management, Mailman School of Public Health, Columbia University, New York, USA.
Int J Public Health. 2019 Dec;64(9):1375-1387. doi: 10.1007/s00038-019-01276-3. Epub 2019 Jun 26.
To examine generational differences in longitudinal blood pressure trajectories by region following socioeconomic transitions, which is important for establishing the population risk of cardiovascular diseases (CVDs).
With data from the China Health and Nutrition Survey (1991-2011), we used multilevel growth-curve models to estimate systolic/diastolic blood pressure (SBP/DBP) levels at the mean age and rates of change by cohort (born between 1931 and 1980), region, and sex.
Younger cohorts generally had higher SBP/DBP levels at 44.5 years but lower growth rates in SBP/DBP than older cohorts. They became prehypertensive (SBP ≥ 120 mm Hg or DBP ≥ 80 mm Hg) at an earlier age. The upward shift of SBP/DBP trajectories across cohorts was more pronounced in the Coastal and Southern Mountainous Regions than the Northeastern and Inland Regions, and for males versus females.
Younger cohorts have a longer lifetime duration of being susceptible to CVDs, posing warnings for an increased burden of CVDs. Generational differences in BP trajectories and geographic and sex variations in the cohort trends highlight the need for tailored interventions to tackle the generation, region, and sex-based risk of CVDs.
通过社会经济转型后各地区的纵向血压轨迹来研究代际差异，这对于确定心血管疾病（CVD）的人群风险非常重要。
本研究利用中国健康与营养调查（1991-2011 年）的数据，采用多水平增长曲线模型，按队列（出生于 1931 年至 1980 年）、地区和性别估计收缩压/舒张压（SBP/DBP）在平均年龄时的水平和变化率。
年轻队列的 SBP/DBP 水平在 44.5 岁时通常较高，但 SBP/DBP 的增长率低于老年队列。他们更早地进入高血压前期（SBP≥120mmHg 或 DBP≥80mmHg）。SBP/DBP 轨迹在各队列之间的上升趋势在沿海和南部山区比东北地区和内陆地区更为明显，在男性中比女性更为明显。
年轻队列一生中易患 CVD 的时间更长，对 CVD 负担的增加发出了警告。BP 轨迹的代际差异以及队列趋势的地域和性别差异突显了需要针对特定人群的干预措施来应对 CVD 的代际、地区和性别风险。
