年轻、中年和老年大鼠淋巴结的收缩活动

Contractile Activity of Lymph Nodes in Young, Middle-Aged, and Old Rats.

作者信息

Demchenko G A, Abdreshov S N, Nurmakhanova B A

机构信息

Laboratory of Lymphatic System Physiology, Institute of Human and Animal Physiology, Ministry of Education and Science of the Republic of Kazakhstan, Almaty, Kazakhstan.

出版信息

Bull Exp Biol Med. 2019 Jun;167(2):194-197. doi: 10.1007/s10517-019-04489-x. Epub 2019 Jun 26.

DOI:10.1007/s10517-019-04489-x

PMID:31243683

Abstract

We studied age-associated changes in contractile activity of isolated cervical and mesenteric lymph nodes in rats. In young and middle-aged rats, no significant changes in contractile activity of lymph nodes were revealed. In old rats, the amplitude of spontaneous contractions of lymph nodes was lower and their rate was higher than in young and middle-aged animals; the sensitivity of lymph nodes to vasoactive agents was reduced and the threshold of the response was higher in old rats.

摘要

我们研究了大鼠离体颈淋巴结和肠系膜淋巴结收缩活动的年龄相关变化。在年轻和中年大鼠中，未发现淋巴结收缩活动有显著变化。在老年大鼠中，淋巴结自发收缩的幅度较低，频率高于年轻和中年动物；老年大鼠淋巴结对血管活性物质的敏感性降低，反应阈值更高。