Qiu Le, Zhang Lei, Turzhitsky Vladimir, Khan Umar, Zakharov Yuri, Kantekure Kanchan, Vitkin Edward, Itzkan Irving, Pleskow Douglas K, Sawhney Mandeep, Berzin Tyler M, Goldsmith Jeffrey D, Perelman Lev T
Center for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
Center for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
IEEE J Sel Top Quantum Electron. 2019 Jan-Feb;25(1). doi: 10.1109/JSTQE.2018.2854608. Epub 2018 Jul 9.
This paper reports the application of endoscopic light scattering spectroscopy (LSS) with light gating to detect malignancies in the biliary and pancreatic ducts, and also reviews the application of endoscopic LSS for differentiating cystic neoplasms in the pancreas and detecting invisible dysplasia in Barrett's esophagus. Information about tissue structure within the superficial epithelium where malignancy starts is present within the spectra of reflected light. Fortunately, this component of the reflected light is not yet randomized. However multiple scattering randomizes the signal from the underlying connective tissue which obscures the desired signal. In order to extract diagnostic information from the reflected signal the multiple scattering component related to connective tissue scattering and absorption must be removed. This is accomplished using described here spatial or polarization gating implemented with endoscopically compatible fiber optic probes.
本文报道了采用光门控的内镜光散射光谱（LSS）技术在检测胆管和胰管恶性肿瘤中的应用，同时还综述了内镜LSS在鉴别胰腺囊性肿瘤以及检测巴雷特食管中隐匿发育异常方面的应用。恶性肿瘤起始的浅表上皮内组织结构信息存在于反射光光谱中。幸运的是，反射光的这一成分尚未随机化。然而，多次散射使来自下方结缔组织的信号随机化，从而掩盖了所需信号。为了从反射信号中提取诊断信息，必须去除与结缔组织散射和吸收相关的多次散射成分。这是通过在此描述的使用与内镜兼容的光纤探头实现的空间或偏振门控来完成的。
