Kluge R
Institute of Pathological Physiology, Karl-Marx-University, Leipzig, GDR.
Acta Physiol Hung. 1987;70(2-3):297-302.
In order to estimate optimum parameters for artificial ventilation of adult guinea pigs, the effect of four hours intermittent positive pressure ventilation (IPPV) was studied using different tidal volumes (VT), respiratory frequencies (f), and minute volumes (Ve). Total compliance was measured by placing the animal in a whole body plathysmograph, the arterial blood gases, pH and base excess by catheterizing the carotid artery. In Series I 9 guinea pigs were ventilated at parameters adapted to the spontaneous breathing pattern (VT = 2 ml, f = 70 breaths.min-1). This ventilatory pattern resulted in severe disorders in compliance, gas exchange, and acid-base balance. In Series II 3 different VT (2, 6, 10 ml) were studied by changing f so that Ve was kept constant. The results demonstrated a favourable effect of slow and deep ventilation upon lung mechanics and oxygenation. In Series III 3 different Ve (300, 250, 200 ml.min-1) were tested using a constant VT = 10 ml. Optimum parameters for artificial ventilation of adult guinea pigs were: VT = 10 ml and f = 20 breath--min-1 which resulted in stable compliance, good O2-saturation, normocapnia and normal acid-base balance.
为了估算成年豚鼠人工通气的最佳参数，研究了使用不同潮气量（VT）、呼吸频率（f）和分钟通气量（Ve）进行4小时间歇性正压通气（IPPV）的效果。通过将动物置于全身体积描记器中测量总顺应性，通过插入颈动脉导管测量动脉血气、pH值和碱剩余。在第一组中，9只豚鼠以适应自主呼吸模式的参数进行通气（VT = 2 ml，f = 70次/分钟）。这种通气模式导致顺应性、气体交换和酸碱平衡出现严重紊乱。在第二组中，通过改变f研究了3种不同的VT（2、6、10 ml），以使Ve保持恒定。结果表明缓慢而深度的通气对肺力学和氧合有良好影响。在第三组中，使用恒定的VT = 10 ml测试了3种不同的Ve（300、250、200 ml/分钟）。成年豚鼠人工通气的最佳参数为：VT = 10 ml，f = 20次/分钟，这导致顺应性稳定、氧饱和度良好、正常碳酸血症和酸碱平衡正常。
