M Tulantched Dieudonne Steve, Min Zhao, Feng Wang-Xiao
Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, PR China.
Future Sci OA. 2019 Feb 12;5(5):FSO375. doi: 10.2144/fsoa-2018-0080. eCollection 2019 Jun.
In this prospective case-control study we aimed to compare diagnostic value of plasma PARK7 and NDKA in early diagnosis of acute stroke and evaluate the validated diagnostic values of PARK7 and NDKA in an independent patient cohort. We then assessed the quantitative relationship between the release of these markers: stroke severity and time. Blood samples were drawn upon hospital admission and 14 days later. PARK7 and NDKA concentrations were measured using an ELISA.
The expression of PARK7 (area under the curve [AUC] = 0.897) in acute stroke patients was more significant than in controls, relative to the NDKA expression (AUC = 0.462); p < 0.05. Their expressions were not related to the clinical characteristics of both groups; p > 0.05.
Even though both markers cannot differentiate stroke etiologies (ischemic or hemorrhagic), plasma PARK7 has better diagnostic value than NDKA for early diagnosis of stroke. 72 plasma samples obtained from acute stroke patients and 78 plasma samples collected from non-stroke patients were analyzed in this study.
在这项前瞻性病例对照研究中，我们旨在比较血浆PARK7和NDKA在急性卒中早期诊断中的诊断价值，并在一个独立的患者队列中评估PARK7和NDKA经过验证的诊断价值。然后，我们评估了这些标志物的释放、卒中严重程度和时间之间的定量关系。在患者入院时和14天后采集血样。使用酶联免疫吸附测定法（ELISA）测量PARK7和NDKA的浓度。
相对于NDKA的表达（曲线下面积[AUC]=0.462），急性卒中患者中PARK7的表达（AUC=0.897）比对照组更显著；p<0.05。它们的表达与两组的临床特征无关；p>0.05。
尽管这两种标志物都不能区分卒中病因（缺血性或出血性），但血浆PARK7在卒中早期诊断中的诊断价值优于NDKA。本研究分析了72份来自急性卒中患者的血浆样本和78份来自非卒中患者的血浆样本。
