Functional Pharmacology and Neuroscience, Department of Surgical Sciences, Uppsala, University, Uppsala, Sweden.
Department of Medical Sciences, Section of Neurosurgery, Uppsala University, Uppsala, Sweden.
Mol Biol Rep. 2024 Jul 13;51(1):803. doi: 10.1007/s11033-024-09708-x.
Acquired brain injury is an urgent situation that requires rapid diagnosis and treatment. Magnetic resonance imaging (MRI) and computed tomography (CT) are required for accurate diagnosis. However, these methods are costly and require substantial infrastructure and specialized staff. Circulatory biomarkers of acute brain injury may help in the management of patients with acute cerebrovascular events and prevent poor outcome and mortality. The purpose of this review is to provide an overview of the development of potential biomarkers of brain damage to increase diagnostic possibilities. For this purpose, we searched the PubMed database of studies on the diagnostic potential of brain injury biomarkers. We also accessed information from Clinicaltrials.gov to identify any clinical trials of biomarker measurements for the diagnosis of brain damage. In total, we present 41 proteins, enzymes and hormones that have been considered as biomarkers for brain injury, of which 20 have been studied in clinical trials. Several microRNAs have also emerged as potential clinical biomarkers for early diagnosis. Combining multiple biomarkers in a panel, along with other parameters, is yielding promising outcomes.
获得性脑损伤是一种紧急情况，需要快速诊断和治疗。磁共振成像（MRI）和计算机断层扫描（CT）是准确诊断所必需的。然而，这些方法成本高昂，需要大量的基础设施和专业人员。急性脑损伤的循环生物标志物可能有助于管理急性脑血管事件，并预防不良结局和死亡率。本综述的目的是提供对潜在脑损伤生物标志物的开发的概述，以增加诊断的可能性。为此，我们在 PubMed 数据库中搜索了关于脑损伤生物标志物诊断潜力的研究。我们还访问了 Clinicaltrials.gov 上的信息，以确定任何用于诊断脑损伤的生物标志物测量的临床试验。总的来说，我们提出了 41 种被认为是脑损伤生物标志物的蛋白质、酶和激素，其中 20 种已经在临床试验中进行了研究。一些 microRNAs 也已成为早期诊断的潜在临床生物标志物。将多个生物标志物组合在一个面板中，并结合其他参数，正在产生有希望的结果。
