Takács E, Hársing J, Füzesi S, Jellinek H
Second Institute of Pathology, Semmelweis University Medical School, Budapest, Hungary.
Acta Morphol Hung. 1987;35(1-2):37-46.
30 rats were divided into 3 experimental groups. These included 8 days of Lipofundin treatment + 8 days recovery period (Group I), 16 days of Lipofundin treatment (Group II), and 16 days of Lipofundin treatment + 8 days recovery period (Group III). After sacrifice semi-thin and ultra-thin sections prepared from the aorta segments were examined light and electron microscopically. In addition to the development of alterations characteristic of the Lipofundin-model, the accumulation of collagen fibres was also observed. After 16 days of Lipofundin treatment the alterations were much more advanced than after 8-day treatment. Subsequent migration of smooth muscle cells through the newly formed internal elastic lamina was apparent and led to thickening of the sclerotic plaque. When the 16-day Lipofundin treatment was followed by a recovery period of 8 days prior to sacrifice, no signs of regression were seen. The alterations were present in unchanged form and the only difference was in the extent of accumulation of collagen fibres.
30只大鼠被分为3个实验组。这些组包括8天的力保肪宁治疗+8天恢复期（第一组）、16天的力保肪宁治疗（第二组）以及16天的力保肪宁治疗+8天恢复期（第三组）。处死后，对取自主动脉段的半薄切片和超薄切片进行光镜和电镜检查。除了出现力保肪宁模型特有的改变外，还观察到胶原纤维的积聚。力保肪宁治疗16天后的改变比8天治疗后的改变要严重得多。随后平滑肌细胞通过新形成的内弹性膜迁移明显，导致硬化斑块增厚。当在处死前对16天的力保肪宁治疗后进行8天的恢复期时，未见消退迹象。改变以未改变的形式存在，唯一的区别在于胶原纤维的积聚程度。
