Schrecker O, Weckermann D, Weckermann J, Jellinek H
Appl Pathol. 1986;4(4):211-8.
Intravenous administration of Lipofundin-S oil, in the rat induces arteriosclerotic lesions within several days. Changes in lipids and lipoproteins were studied by lipid electrophoresis, ultracentrifugation and gel filtration. One hour after injection of Lipofundin, a dramatic increase occurred in triglycerides and phospholipids, reflecting the composition of the lipid emulsion. During a period of 6-7 h the lipid concentrations normalized by hydrolysis. Repeated injections (every 12 h) of Lipofundin-S led to persisting changes in the lipoprotein concentrations within 2-4 days. Very-low-density and high-density lipoprotein (alpha-lipoprotein) levels decreased, whereas low-density lipoprotein (beta-lipoprotein) levels increased. The beta-/alpha-lipoprotein ratio, as determined from the peak areas of the lipoprotein electrophoresis pattern, increased significantly. The alterations of this 'atherogenic index' may cause the atherosclerotic lesions observed in the aorta of animals which are normally resistant to atherosclerosis.
给大鼠静脉注射 Lipofundin-S 油，数天内会诱发动脉粥样硬化病变。通过脂质电泳、超速离心和凝胶过滤研究脂质和脂蛋白的变化。注射 Lipofundin 一小时后，甘油三酯和磷脂显著增加，反映了脂质乳剂的成分。在 6 - 7 小时内，脂质浓度通过水解恢复正常。重复注射（每 12 小时一次）Lipofundin-S 导致脂蛋白浓度在 2 - 4 天内持续变化。极低密度脂蛋白和高密度脂蛋白（α-脂蛋白）水平降低，而低密度脂蛋白（β-脂蛋白）水平升高。根据脂蛋白电泳图谱峰面积确定的β/α-脂蛋白比值显著增加。这种“致动脉粥样硬化指数”的改变可能导致在通常对动脉粥样硬化有抵抗力的动物主动脉中观察到的动脉粥样硬化病变。
