Stiborova K, Treggiari E, Amores-Fuster I, Del Busto I, Killick D, Maddox T, Marrington M, Mason S L, Blackwood L
Department of Small Animal Clinical Science, Leahurst Campus, University of Liverpool, Neston, CH64 7TE, UK.
Centro Specialistico Veterinario, 20141, Milan, Italy.
J Small Anim Pract. 2019 Sep;60(9):534-542. doi: 10.1111/jsap.13047. Epub 2019 Jun 27.
To determine whether dogs with surgically excised mast cell tumours receiving a vinblastine/prednisolone chemotherapy protocol in combination with radiation therapy are at greater risk of myelosuppression than patients receiving the chemotherapy protocol alone.
Retrospective study of clinical records of dogs with mast cell tumours that, subsequent to surgical excision, had received combination vinblasine/prednisolone chemotherapy. Dogs were assigned to two groups: those treated with adjunctive radiotherapy and vinblastine/prednisolone (RT group) and those treated with surgery followed by vinblastine/prednisolone alone (control group). Haematology results were compared between groups.
Forty-three cases and 43 controls of similar breed, age and bodyweight were included. Concurrent radiation and vinblastine chemotherapy did not appear to increase the risk of neutropenia, which was observed in 18.6 and 23.2% of cases in the RT and control groups, respectively.
Radiation and vinblastine chemotherapy can be safely combined in dogs with mast cell tumours without increasing the risk of clinically important myelosuppression.
确定接受长春碱/泼尼松龙化疗方案联合放射治疗的手术切除肥大细胞瘤犬，与仅接受化疗方案的犬相比，是否有更高的骨髓抑制风险。
对手术切除后接受长春碱/泼尼松龙联合化疗的肥大细胞瘤犬的临床记录进行回顾性研究。犬被分为两组：接受辅助放疗及长春碱/泼尼松龙治疗的犬（放疗组）和仅接受手术及后续长春碱/泼尼松龙治疗的犬（对照组）。比较两组的血液学结果。
纳入了43例病例和43例品种、年龄和体重相似的对照犬。同时进行放疗和长春碱化疗似乎并未增加中性粒细胞减少的风险，放疗组和对照组分别有18.6%和23.2%的病例出现中性粒细胞减少。
放射治疗和长春碱化疗可安全地联合用于患有肥大细胞瘤的犬，而不会增加临床上重要的骨髓抑制风险。
