Anderson Kristina, Pellin MacKenzie, Snyder Elizabeth, Clarke Dawn
Blue Pearl Pet Hospital, Southfield, MI 48034, USA.
Department of Medical Sciences, Veterinary Medical Teaching Hospital, University of Wisconsin-Madison, Madison, WI 53706, USA.
Vet Sci. 2024 Aug 10;11(8):363. doi: 10.3390/vetsci11080363.
Canine cutaneous mast cell tumors (cMCTs) have variable rates of recurrence and metastasis. We evaluated how various prognostic factors affect survival, recurrence, and metastasis in dogs with cMCT who underwent surgery and vinblastine chemotherapy.
90 dogs with cMCT treated with surgery and vinblastine at a veterinary referral institution were included.
Medical records were retrospectively reviewed. Prognostic factors were evaluated.
Most dogs (94%) had grade 2 or 3 cMCTs. Neoadjuvant vinblastine was used in 18 dogs, and none progressed locally before surgery. The use of neoadjuvant vinblastine was associated with a higher chance of local recurrence ( = 0.03) but not survival. Shorter survival times were found for tumors that were high-grade ( < 0.001), grade 3 ( < 0.001), or a MC of >5 ( < 0.001). Dogs with grade 2 tumors that were low-grade lived longer than those with high-grade tumors ( < 0.001). Histologic tumor-free margins and the ability to achieve local tumor control were not associated with outcome.
Both grading systems and MC were prognostic for survival in this population of dogs, supporting the need for the standard reporting of histopathologic findings. Neoadjuvant chemotherapy can be effective in downsizing cMCTs but does not influence survival. These findings are consistent with previous publications, showing the benefits of a more modern population of patients, surgical treatments, and histopathologic assessments.
犬皮肤肥大细胞瘤（cMCTs）具有不同的复发率和转移率。我们评估了各种预后因素如何影响接受手术和长春碱化疗的cMCT犬的生存、复发和转移情况。
纳入了90只在兽医转诊机构接受手术和长春碱治疗的cMCT犬。
对病历进行回顾性审查。评估预后因素。
大多数犬（94%）患有2级或3级cMCT。18只犬使用了新辅助长春碱，且术前均无局部进展。新辅助长春碱的使用与局部复发几率较高相关（=0.03），但与生存率无关。高级别（<0.001）、3级（<0.001）或有丝分裂计数>5（<0.001）的肿瘤生存时间较短。2级低级别肿瘤的犬比高级别肿瘤的犬寿命更长（<0.001）。组织学无瘤切缘和实现局部肿瘤控制的能力与预后无关。
分级系统和有丝分裂计数对该犬群的生存均具有预后意义，支持对组织病理学结果进行标准报告的必要性。新辅助化疗可有效缩小cMCT的大小，但不影响生存率。这些发现与先前的出版物一致，显示了更现代的患者群体、手术治疗和组织病理学评估的益处。
