可见光驱动的C(sp)-H键烷基化反应通过1,6-氢原子转移/自由基接力加成实现。
Visible Light Driven Alkylation of C(sp)-H Bonds Enabled by 1,6-Hydrogen Atom Transfer/Radical Relay Addition.
作者信息
Ma Zhi-Yong, Guo Li-Na, You Ying, Yang Fan, Hu Mingyou, Duan Xin-Hua
机构信息
Department of Chemistry, School of Science, Xi'an Key Laboratory of Sustainable Energy Material Chemistry and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter , Xi'an Jiaotong University , Xi'an 710049 , P. R. China.
State Key Laboratory of Applied Organic Chemistry , Lanzhou University , Lanzhou 730000 , P. R. China.
出版信息
Org Lett. 2019 Jul 19;21(14):5500-5504. doi: 10.1021/acs.orglett.9b01804. Epub 2019 Jun 27.
A visible-light-driven sulfamate esters guided alkylation of unactivated C(sp)-H bonds enabled by a 1,6-HAT/radical addition cascade is described. Not only structurally diverse Michael acceptors but also styrenes are amenable to this alkylation reaction. Notably, the N-H bonds activation radical relay refrained from prefunctionalization and using excess external oxidants.
本文描述了一种可见光驱动的、由1,6-氢原子转移/自由基加成串联反应实现的氨基磺酸酯导向的未活化C(sp)-H键烷基化反应。不仅结构多样的迈克尔受体，而且苯乙烯都适用于这种烷基化反应。值得注意的是，N-H键活化自由基接力避免了预官能团化和使用过量的外部氧化剂。
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