Department of Psychiatry.
Division of Addiction Psychiatry.
Psychol Addict Behav. 2020 Feb;34(1):230-241. doi: 10.1037/adb0000472. Epub 2019 Jun 27.
Cannabis use and related disorders are common in adults and frequently co-occur with subsyndromal and pathological gambling. However, understanding how cannabis use may moderate relationships between problem-gambling severity and psychiatric disorders remains poorly understood. Data from the National Epidemiological Survey on Alcohol and Related Conditions ( = 43,093 adults) were examined to investigate how cannabis use moderated associations between problem-gambling severity (with gambling groups based on the 10 inclusionary criteria for pathological gambling) and Axis I and Axis II psychiatric disorders. Problem-gambling severity groups included low frequency/nongambling, low-risk gambling, at-risk gambling, and problem/pathological gambling (PPG). Among both the group with lifetime cannabis use and that which never used cannabis, greater problem-gambling severity was associated with more psychopathology across mood, anxiety, substance-use and Axis II disorders. Significant Cannabis Use × Problem-Gambling Severity Group interactions were observed between PPG and major depression ( = 0.35, 95% CI = [0.14-0.85]), cluster A personality disorders ( = 0.37, 95% CI = [0.16-0.86])-especially paranoid personality disorder ( = 0.34, 95% CI = [0.14-0.81])-and cluster B personality disorders ( = 0.36, 95% CI = [0.18-0.75])-especially antisocial personality disorder ( = 0.25, 95% CI = [0.11-0.60]). In all cases, associations between problem-gambling severity and psychopathologies were weaker among the lifetime-cannabis-using group as compared to the never-using group. Cannabis use moderates the relationships between problem-gambling severity and psychiatric disorders, with cannabis use appearing to account for some of the variance in the associations between greater problem-gambling severity and specific forms of psychopathology. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
大麻使用与相关障碍在成年人中很常见，且常与亚综合征和病态赌博共病。然而，对于大麻使用如何调节赌博严重程度与精神障碍之间的关系，目前人们知之甚少。本研究使用来自全国酒精相关情况调查（ = 43,093 名成年人）的数据，探讨了大麻使用如何调节赌博严重程度（基于病理性赌博的 10 项纳入标准对赌博组进行分组）与轴 I 和轴 II 精神障碍之间的关联。赌博严重程度分组包括低频率/不赌博、低风险赌博、风险赌博和问题/病态赌博（PPG）。在有终生大麻使用史的组和从未使用过大麻的组中，赌博严重程度越高，心境、焦虑、物质使用和轴 II 障碍相关的精神病理学表现越多。在 PPG 与重度抑郁症（ = 0.35，95%CI = [0.14-0.85]）、A 类人格障碍（ = 0.37，95%CI = [0.16-0.86]）-特别是偏执型人格障碍（ = 0.34，95%CI = [0.14-0.81]）和 B 类人格障碍（ = 0.36，95%CI = [0.18-0.75]）-特别是反社会型人格障碍（ = 0.25，95%CI = [0.11-0.60]）之间观察到显著的大麻使用 × 赌博严重程度分组交互作用。在所有情况下，与终生使用大麻的组相比，从不使用大麻的组中，赌博严重程度与精神病理学之间的关联较弱。大麻使用调节了赌博严重程度与精神障碍之间的关系，大麻使用似乎解释了在赌博严重程度与特定形式的精神病理学之间的关联中存在的部分变异性。（APA，所有权利保留）。
