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抗生素:在儿童牙科中的使用和滥用。系统评价。

Antibiotics: their use and misuse in paediatric dentistry. A systematic review.

机构信息

Paediatric Dentistry Postgraduate Program, Modern Dental College and Research Centre, Indore, India.

出版信息

Eur J Paediatr Dent. 2019 Jun;20(2):133-138. doi: 10.23804/ejpd.2019.20.02.10.

Abstract

AIM

The use of antibiotics by health care professionals has benefitted humankind to a great extent. Recent reports show an increasing trend of antibiotic prescription by paediatric dentists. This systematic review aims to address the current pattern of antibiotics prescription among the paediatric dental population according to the evidence-based literature. The question of research addressed here deals with the assessment of the correlation of the injudicious prescription of antibacterial agents and antibiotic resistance among the population of interest.

METHODS

Electronic search databases: PubMed, Ovid and Cochrane Library, were used to review studies as per their relevance and findings. Keywords for search were associated with population: 'paediatric patients', intervention: 'antibiotics treatment', 'prescribing behaviour', and outcomes: 'antibiotic resistance' RESULTS: A total of 542 abstracts were identified, 45 of which met the inclusion criteria and were reviewed. A multifactorial relationship leading to increased prescription of antibiotics in paediatric dentistry was observed. Very few studies actually correlated this prescribing behaviour with resistance to these drugs. No consensus regarding the duration of antibiotic therapy or prophylaxis was found.

CONCLUSION

Insufficient literature support necessitates the requirement of increased evidence to draw a definitive association between the prescribing trends of antibiotics in paediatric dentistry and drug resistance. The development of intervention programmes like antibiotic stewardship ensuring collaboration between patients and paediatric dentists can ensure effective antibiotic prescription.

摘要

目的

医疗保健专业人员使用抗生素在很大程度上使人类受益。最近的报告显示,儿科牙医开具抗生素处方的趋势呈上升趋势。本系统评价旨在根据循证文献,针对儿科牙科人群的抗生素处方模式。这里研究的问题涉及评估抗菌药物不合理处方与目标人群抗生素耐药性之间的相关性。

方法

电子搜索数据库:PubMed、Ovid 和 Cochrane Library,用于根据相关性和研究结果对研究进行回顾。搜索的关键词与人群相关:“儿科患者”、干预措施:“抗生素治疗”、“处方行为”和结果:“抗生素耐药性”。

结果

共确定了 542 篇摘要,其中 45 篇符合纳入标准并进行了回顾。观察到导致儿科牙科抗生素处方增加的多因素关系。实际上很少有研究将这种处方行为与这些药物的耐药性相关联。对于抗生素治疗或预防的持续时间没有达成共识。

结论

文献支持不足,需要增加证据来确定儿科牙科抗生素处方趋势与耐药性之间的明确关联。制定抗生素管理等干预计划,确保患者和儿科牙医之间的合作,可以确保有效的抗生素处方。

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