Kawahara E, Oda Y, Ooi A, Katsuda S, Nakanishi I, Umeda S
School of Medicine, Department of Pathology, Kanazawa University, Ishikawa, Japan.
Am J Surg Pathol. 1988 Feb;12(2):115-20. doi: 10.1097/00000478-198802000-00004.
Immunoreactivity of glial fibrillary acidic protein (GFAP) in 38 schwannomas and 18 neurofibromas was evaluated and compared with the reactivity of vimentin, S-100 protein, and neurofilament protein. All cases were positive for vimentin and S-100 protein. GFAP was positively stained in the neoplastic cells of 15 of 38 schwannomas (38%) and in two of 18 neurofibromas (11%). The extensively stained GFAP-positive tumors tended to be deeply situated in the body. The GFAP-positive cells were usually spindle-shaped and appeared preferentially in the perivascular region of hyalinized, thick blood vessels.
评估了38例神经鞘瘤和18例神经纤维瘤中胶质纤维酸性蛋白（GFAP）的免疫反应性，并与波形蛋白、S-100蛋白和神经丝蛋白的反应性进行了比较。所有病例的波形蛋白和S-100蛋白均呈阳性。38例神经鞘瘤中有15例（38%）的肿瘤细胞GFAP呈阳性染色，18例神经纤维瘤中有2例（11%）呈阳性染色。GFAP广泛染色阳性的肿瘤往往位于身体较深处。GFAP阳性细胞通常呈梭形，优先出现在玻璃样变、增厚血管的血管周围区域。
