The Dodd-Walls Centre for Photonic and Quantum Technologies, Department of Chemistry , University of Otago , Dunedin 9016 , New Zealand.
Department of Pharmacy, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen 1165 , Denmark.
Mol Pharm. 2019 Aug 5;16(8):3678-3686. doi: 10.1021/acs.molpharmaceut.9b00557. Epub 2019 Jul 10.
A series of melt-quenched disks of amorphous celecoxib were obtained using two different cooling rates (>100 °C/min and ∼25-30 °C/min) and subjected to different compression pressures (125, 250, and 500 MPa) and dwell times (0, 30, and 60 s). The kinetics of crystallization for these differently prepared melt-quenched disks were probed using a number of methods. Low-frequency Raman spectroscopy was used to monitor isothermal crystallization kinetics, whereas dynamic differential scanning calorimetry served as a complimentary technique to identify changes in form. Although both compression parameters destabilized the amorphous celecoxib, the dwell time was found to have a more critical overall effect. Additionally, the sample history was affirmed to be a factor for limiting the magnitude of compression-induced destabilization.
采用两种不同冷却速率（>100°C/min 和 ∼25-30°C/min）和不同压缩压力（125、250 和 500 MPa）和停留时间（0、30 和 60 s）获得了一系列无定形塞来昔布的熔体淬火盘。使用多种方法研究了这些不同制备的熔体淬火盘的结晶动力学。低频拉曼光谱用于监测等温结晶动力学，而动态差示扫描量热法则作为一种补充技术来识别形态变化。尽管两种压缩参数都使无定形塞来昔布失稳，但停留时间被发现具有更关键的总体影响。此外，样品历史被确认为限制压缩诱导失稳程度的一个因素。
