The Dodd-Walls Centre for Photonic and Quantum Technologies, Department of Chemistry, University of Otago, Dunedin 9016, New Zealand.
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 1165, Denmark.
Anal Chem. 2022 Jun 14;94(23):8241-8248. doi: 10.1021/acs.analchem.2c00371. Epub 2022 Jun 1.
In an earlier investigation, low-frequency Raman (LFR) spectroscopy was shown to detect the transition temperature of the β-relaxation () in both amorphous celecoxib and various celecoxib amorphous solid dispersions [Be̅rziņš, K. 2021, 18(10), 3882-3893]. In this study, we further investigated the application of this technique to determine , an important parameter for estimating crystallization potency of amorphous drugs. Alongside commercially available amorphous drugs (zafirlukast and valsartan disodium salt), differently melt-quenched samples of cimetidine were also analyzed. Overall, the variable-temperature LFR measurements allowed for an easy access to the desired information, including the even lesser transition of the tertiary relaxation motions (). Thus, the obtained results not only highlighted the sensitivity, but also the practical usefulness of this technique to elucidate (subtle) changes in molecular dynamics within amorphous pharmaceutical systems.
在早期的研究中，低频拉曼（LFR）光谱被证明可以检测无定形塞来昔布和各种塞来昔布无定形固体分散体中β弛豫（）的转变温度[Be̅rziņš，K. 2021，18（10），3882-3893]。在这项研究中，我们进一步研究了该技术在确定β的应用，这是估计无定形药物结晶能力的一个重要参数。除了市售的无定形药物（扎鲁司特和缬沙坦二钠盐）外，还分析了不同熔融淬火的西咪替丁样品。总的来说，变温 LFR 测量使得很容易获得所需的信息，包括三级弛豫运动（）的较小转变。因此，所获得的结果不仅突出了该技术的灵敏度，而且还突出了其在阐明无定形药物系统中分子动力学（细微）变化方面的实际有用性。
