State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences , University of Macau , Macao , China.
Department of Chemistry , Southern University of Science and Technology , Shenzhen 518055 , China.
Org Lett. 2019 Jul 19;21(14):5575-5580. doi: 10.1021/acs.orglett.9b01907. Epub 2019 Jun 27.
A CuH-catalyzed atropoenantioselective reduction of Bringmann's lactones via dynamic kinetic resolution has been disclosed. This protocol features a broad substrate scope and good functional group tolerance and allows the rapid assembly of various valuable axially chiral biaryls in good to high yields (up to 92% yield) with high to excellent enantioselectivities (up to 96% ee). Moreover, this report represents a rare example that a carbonyl group of esters is reduced under homogeneous asymmetric CuH catalysis.
一种通过动态动力学拆分实现的 CuH 催化的 Bringmann 内酯的非对映选择性还原被揭示。该方案具有广泛的底物范围和良好的官能团耐受性，并允许在高至优秀的对映选择性（高达 96%ee）下以良好至高收率（高达 92%收率）快速组装各种有价值的轴手性联苯。此外，该报告代表了在均相不对称 CuH 催化下酯的羰基被还原的罕见实例。
