Faculty of Medicine and Health Sciences, University of Barcelona, C/Feixa Lllarga, s/n, Pavelló de Govern, 2 planta, Despatx 2.9, 08907 L'Hospitalet de Llobregat, Barcelona, Spain,
Med Oral Patol Oral Cir Bucal. 2019 Jul 1;24(4):e425-e432. doi: 10.4317/medoral.22889.
Oral bone regeneration techniques (OBRT) attempt to provide the appropriate bone volume and density to correctly accomplish dental implant treatments. The objective was to determine whether differences exist in the clinical outcomes of these techniques between diabetic and non-diabetic patients, considering the level of scientific evidence.
A systematic review following PRISMA statements was conducted in the PubMed, Scopus and Cochrane databases with the search terms: "Diabetes Mellitus", "guided bone regeneration", "bone regeneration", "alveolar ridge augmentation", "ridge augmentation", bone graft*, "sinus floor augmentation", "sinus floor elevation", "sinus lift", implant*. Articles were limited to those published less than 10 years ago and in English. Inclusion criteria were: human studies of all bone regeneration techniques, including at least 10 patients and the using OBRT in diabetic and non-diabetic patients. Non-human studies were excluded. They were stratified according to their level of scientific evidence related to SORT criteria (Strength of Recommendation Taxonomy).
The initial search provided 131 articles, after reading the abstracts a total of 33 relevant articles were selected to read the full text and analyzed to decide eligibility. Finally, seven of them accomplished the inclusion criteria: two controlled clinical trials, one cohort study and four case series.
A low grade of evidence regarding the use of OBRT in diabetic patients was found. The recommendation for this intervention in diabetic patients is considered type C due to the high heterogeneity of the type of diabetic patients included and the variability of the techniques applied.
口腔骨再生技术（OBRT）旨在提供适当的骨量和密度，以正确完成牙种植治疗。目的是确定在考虑科学证据水平的情况下，这些技术在糖尿病和非糖尿病患者中的临床结果是否存在差异。
按照 PRISMA 声明，在 PubMed、Scopus 和 Cochrane 数据库中进行了系统评价，使用的检索词为：“糖尿病”、“引导骨再生”、“骨再生”、“牙槽嵴增高”、“牙槽嵴增高”、“骨移植”、“鼻窦底增高”、“鼻窦底提升”、“鼻窦提升”、“植入物”。文章仅限于发表时间不超过 10 年且为英文的研究。纳入标准为：所有骨再生技术的人类研究，包括至少 10 名患者，并在糖尿病和非糖尿病患者中使用 OBRT。排除非人类研究。根据与 SORT 标准（推荐强度分类）相关的科学证据水平对其进行分层。
最初的搜索提供了 131 篇文章，在阅读摘要后，共选择了 33 篇相关文章阅读全文并进行分析，以确定是否符合入选标准。最终，其中 7 篇符合纳入标准：2 项对照临床试验、1 项队列研究和 4 项病例系列研究。
发现 OBRT 在糖尿病患者中的应用证据等级较低。由于纳入的糖尿病患者类型和应用技术的变异性较高，因此建议将这种干预措施作为 C 型。
