Erdogan Özgür, Uçar Yurdanur, Tatlı Ufuk, Sert Murat, Benlidayı Mehmet Emre, Evlice Burcu
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çukurova University, Adana, Turkey.
Faculty of Dental Medicine, Rangsit University, Pathumthani, Bangkok, Thailand.
Clin Oral Implants Res. 2015 Nov;26(11):1267-75. doi: 10.1111/clr.12450. Epub 2014 Jul 11.
The objective of this prospective, controlled clinical study was to determine the outcomes of dental implant therapy with staged guided bone regeneration procedures in patients with type 2 diabetes.
Twenty-four patients were included in the study. Half of the patients were diagnosed with type 2 diabetes mellitus (group 1) while the other half (group 2) of the patients consisted of patients without diabetes. The edentulous maxillary anterior/premolar regions with sufficient vertical height but inadequate horizontal width were treated with staged guided bone regeneration technique and with one or two implant-supported fixed restorations. The patients were followed up at least for 12 months. The parameters that were evaluated were radiographic evaluations on CBCT images and periapical radiographs, histomorphometric analysis, resonance frequency analysis (RFA) and wound-healing parameters. The data were analyzed statistically.
A total of 43 implants were placed in 24 patients (22 implants in group 1 and 21 implants in group 2). The survival rates of implants were 100% for both groups. The success rate of implants was 95% for group 1 and 100% for group 2. None of the parameters including CBCT findings, RFA values, success rates and wound-healing scores showed a significant difference between the two groups.
Staged guided bone regeneration is a feasible augmentation procedure for the treatment of horizontal bone deficiencies of the maxillary anterior/premolar regions in well-controlled type 2 diabetic patients.
本前瞻性对照临床研究的目的是确定2型糖尿病患者采用分期引导骨再生程序进行牙种植治疗的效果。
本研究纳入了24例患者。其中一半患者被诊断为2型糖尿病（第1组），另一半患者（第2组）为非糖尿病患者。对上颌无牙的前牙/前磨牙区，垂直高度足够但水平宽度不足的区域，采用分期引导骨再生技术，并进行一个或两个种植体支持的固定修复。对患者进行至少12个月的随访。评估的参数包括CBCT图像和根尖片的影像学评估、组织形态计量分析、共振频率分析（RFA）和伤口愈合参数。对数据进行统计学分析。
24例患者共植入43枚种植体（第1组22枚，第2组21枚）。两组种植体的生存率均为100%。第1组种植体的成功率为95%，第2组为100%。包括CBCT结果、RFA值、成功率和伤口愈合评分在内的所有参数在两组之间均无显著差异。
对于病情控制良好的2型糖尿病患者，分期引导骨再生是治疗上颌前牙/前磨牙区水平骨缺损的一种可行的增量手术。
