Jordan Caroline D, Thorne Bradford R H, Wadhwa Arjun, Losey Aaron D, Ozhinsky Eugene, Kondapavulur Sravani, Fratello Vincent, Moore Teri, Stillson Carol, Yee Colin, Watkins Ronald D, Scott Greig C, Martin Alastair J, Zhang Xiaoliang, Wilson Mark W, Hetts Steven W
IEEE Trans Biomed Eng. 2020 Mar;67(3):876-882. doi: 10.1109/TBME.2019.2922879. Epub 2019 Jun 21.
Interventional magnetic resonance imaging (MRI) could allow for diagnosis and immediate treatment of ischemic stroke; however, such endovascular catheter-based procedures under MRI guidance are inherently difficult. One major challenge is tracking the tip of the catheter, as standard fabrication methods for building inductively coupled coil markers are rigid and bulky. Here, we report a new approach that uses aerosol jet deposition to three-dimensional (3-D) print an inductively coupled RF coil marker on a polymer catheter. Our approach enables lightweight conforming markers on polymer catheters and these low-profile markers allow the catheter to be more safely navigated in small caliber vessels. Prototype markers with an inductor with the geometry of a double helix are incorporated on catheters for in vitro studies, and we show that these markers exhibit good signal amplification. We report temperature measurements and, finally, demonstrate feasibility in a preliminary in vivo experiment. We provide material properties and electromagnetic simulation performance analysis. This paper presents fully aerosol jet-deposited and functional wireless resonant markers on polymer catheters for use in 3T clinical scanners.
介入式磁共振成像(MRI)可实现缺血性中风的诊断与即时治疗;然而,在MRI引导下进行此类基于血管内导管的操作本身具有难度。一个主要挑战是追踪导管尖端,因为用于制造电感耦合线圈标记的标准方法所制得的标记坚硬且笨重。在此,我们报告一种新方法,即使用气溶胶喷射沉积在聚合物导管上三维(3-D)打印电感耦合射频线圈标记。我们的方法能够在聚合物导管上制造出轻质贴合的标记,这些低轮廓标记使导管能够在小口径血管中更安全地导航。带有双螺旋几何形状电感的原型标记被整合到导管上用于体外研究,并且我们表明这些标记具有良好的信号放大效果。我们报告了温度测量结果,最后在初步体内实验中证明了其可行性。我们提供了材料特性和电磁模拟性能分析。本文展示了在聚合物导管上完全通过气溶胶喷射沉积制成的功能性无线谐振标记,可用于3T临床扫描仪。