通过苯二炔与三氟磺酸的阳离子环加成合成萘基三氟甲磺酸酯。
Synthesis of Naphthalenyl Triflates via the Cationic Annulation of Benzodiynes with Triflic Acid.
机构信息
Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry , Tsinghua University , Beijing 100084 , China.
School of Chemical & Environmental Engineering , Wuyi University , Jiangmen 529000 , China.
出版信息
Org Lett. 2019 Jul 5;21(13):5010-5014. doi: 10.1021/acs.orglett.9b01590. Epub 2019 Jun 24.
A highly efficient and regioselective annulation of benzodiynes promoted by triflic acid has been developed. This protocol provides a step and atom-economic access to a series of naphthalenyl triflates. Furthermore, direct synthetic applications of this reaction are also elaborated through cross-coupling reactions to generate synthetically useful multisubstituted naphthalenes.
三氟磺酸促进的高活性和区域选择性苯并二炔环化反应已被开发。该方法为一系列萘基三氟甲磺酸酯提供了一种简洁高效、原子经济性的合成途径。此外，通过交叉偶联反应对该反应进行了直接的合成应用，生成了具有合成价值的多取代萘。
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