Department of Biomolecular Systems , Max Planck Institute of Colloids and Interfaces , Am Mühlenberg 1 , 14476 Potsdam , Germany.
Department of Chemistry and Biochemistry , Freie Universität Berlin , Arnimallee 22 , 14195 Berlin , Germany.
Org Lett. 2019 Jul 5;21(13):5331-5334. doi: 10.1021/acs.orglett.9b01957. Epub 2019 Jun 24.
A carbon nitride material can be combined with homogeneous nickel catalysts for light-mediated cross-couplings of aryl bromides with alcohols under mild conditions. The metal-free heterogeneous semiconductor is fully recyclable and couples a broad range of electron-poor aryl bromides with primary and secondary alcohols as well as water. The application for intramolecular reactions and the synthesis of active pharmaceutical ingredients was demonstrated. The catalytic protocol is applicable for the coupling of aryl iodides with thiols as well.
一种氮化碳材料可以与均相镍催化剂结合，在温和条件下实现芳基溴化物与醇的光介导交叉偶联。这种无金属的异质半导体是完全可回收的，可以将广泛的缺电子芳基溴化物与伯醇和仲醇以及水偶联。该催化体系还可应用于分子内反应和活性药物成分的合成。该催化方案也适用于芳基碘化物与硫醇的偶联。
