Department of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.
Org Lett. 2018 Mar 16;20(6):1580-1583. doi: 10.1021/acs.orglett.8b00325. Epub 2018 Feb 23.
Two catalyst systems are described, which together provide mild and general conditions for the Pd-catalyzed C-O cross-coupling of primary alcohols. For activated substrates, such as electron-deficient aryl halides, the commercially available ligand L2 promotes efficient coupling for a variety of alcohol nucleophiles. In the case of unactivated electrophiles, such as electron-rich aryl halides, the new ligand L8 was developed to improve these challenging C-O bond-forming reactions.
介绍了两种催化剂体系，它们共同为 Pd 催化的伯醇的 C-O 交叉偶联提供了温和且通用的条件。对于活性底物，如缺电子的芳基卤化物，商业上可用的配体 L2 促进了各种醇亲核试剂的有效偶联。对于非活性亲电试剂，如富电子的芳基卤化物，开发了新的配体 L8 以改善这些具有挑战性的 C-O 键形成反应。
