随时可用的HCN：按需连续生产用于有机合成的无水HCN。
HCN on Tap: On-Demand Continuous Production of Anhydrous HCN for Organic Synthesis.
作者信息
Köckinger Manuel, Hone Christopher A, Kappe C Oliver
机构信息
Center for Continuous Flow Synthesis and Processing (CCFLOW) , Research Center Pharmaceutical Engineering GmbH (RCPE) , Inffeldgasse 13 , 8010 Graz , Austria.
Institute of Chemistry , University of Graz , Heinrichstraße 28 , A-8010 Graz , Austria.
出版信息
Org Lett. 2019 Jul 5;21(13):5326-5330. doi: 10.1021/acs.orglett.9b01941. Epub 2019 Jun 19.
A continuous process for the on-demand generation, separation, and reaction of hydrogen cyanide (HCN) using membrane separation technology was developed. The inner tube of the reactor is manufactured from a gas-permeable, hydrophobic fluoropolymer (Teflon AF-2400) membrane. HCN is formed from aqueous reagents within the inner tube and then diffuses through the membrane into an outer tubing containing organic solvent. This technique enabled the safe handling of HCN for three different organic transformations without the need for distillation.
开发了一种使用膜分离技术按需生成、分离和反应氰化氢（HCN）的连续工艺。反应器的内管由透气的疏水性含氟聚合物（Teflon AF - 2400）膜制成。HCN在内管中由水性试剂形成，然后通过膜扩散到含有有机溶剂的外管中。该技术能够安全地处理HCN以进行三种不同的有机转化，而无需蒸馏。
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