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葡萄膜黑色素瘤与皮肤黑色素瘤；起源相同，肿瘤类型却截然不同。

Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types.

作者信息

van der Kooij Monique K, Speetjens Frank M, van der Burg Sjoerd H, Kapiteijn Ellen

机构信息

Department of Medical Oncology, Oncode Institute, Leiden University Medical Center, Albinusdreef 2, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

Department of Medical Oncology, Leiden University Medical Center, Albinusdreef 2, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

出版信息

Cancers (Basel). 2019 Jun 19;11(6):845. doi: 10.3390/cancers11060845.

DOI:10.3390/cancers11060845
PMID:31248118
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6627906/
Abstract

Here, we critically evaluated the knowledge on cutaneous melanoma (CM) and uveal melanoma (UM). Both cancer types derive from melanocytes that share the same embryonic origin and display the same cellular function. Despite their common origin, both CM and UM display extreme differences in their genetic alterations and biological behavior. We discuss the differences in genetic alterations, metastatic routes, tumor biology, and tumor-host interactions in the context of their clinical responses to targeted- and immunotherapy.

摘要

在此，我们对皮肤黑色素瘤（CM）和葡萄膜黑色素瘤（UM）的相关知识进行了批判性评估。这两种癌症类型均起源于黑素细胞，它们具有相同的胚胎起源并表现出相同的细胞功能。尽管起源相同，但CM和UM在基因改变和生物学行为方面存在极大差异。我们在它们对靶向治疗和免疫治疗的临床反应背景下，讨论了基因改变、转移途径、肿瘤生物学以及肿瘤与宿主相互作用方面的差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/6627906/12fa68de634c/cancers-11-00845-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/6627906/12fa68de634c/cancers-11-00845-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/6627906/12fa68de634c/cancers-11-00845-g001.jpg

相似文献

[1]
Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types.

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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[10]
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引用本文的文献

[1]
Choroidal Metastasis Presenting As Anterior and Posterior Scleritis: A Rare Manifestation of a Previously Unknown Metastatic Cutaneous Melanoma.

Cureus. 2025-8-7

[2]
Monitoring soluble cMET and ctDNA in metastatic uveal melanoma patients to track early disease progression on immunotherapies.

J Exp Clin Cancer Res. 2025-7-19

[3]
Short Report: The Variants in in Metastatic Uveal Melanoma.

J Clin Med. 2025-4-18

[4]
Presumed Choroidal Metastasis of Primary Cutaneous Melanoma: A Case Report.

Case Rep Ophthalmol. 2025-3-24

[5]
Selinexor (KPT-330) in Combination with Immune Checkpoint Inhibition in Uveal Melanoma: A Phase 1B Trial.

J Immunother Precis Oncol. 2025-1-15

[6]
Targeting Matrix Metalloproteinases and Their Inhibitors in Melanoma.

Int J Mol Sci. 2024-12-18

[7]
Metastatic conjunctival melanoma: a multicentre international study.

Br J Ophthalmol. 2025-5-30

[8]
Overcoming Resistance Mechanisms to Melanoma Immunotherapy.

Am J Clin Dermatol. 2025-1

[9]
Proton Therapy in Uveal Melanoma.

Cancers (Basel). 2024-10-16

[10]
Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastases.

Elife. 2024-9-23

本文引用的文献

[1]
BRAF mutational status as a prognostic marker for survival in malignant melanoma: a systematic review and meta-analysis.

Acta Oncol. 2020-7

[2]
Knockdown of FBXO22 inhibits melanoma cell migration, invasion and angiogenesis via the HIF-1α/VEGF pathway.

Invest New Drugs. 2019-3-18

[3]
Mutation Status in Primary, Recurrent, and Metastatic Malignant Melanoma and Its Relation to Histopathological Parameters.

Dermatol Pract Concept. 2019-1-31

[4]
KIT as an Oncogenic Driver in Melanoma: An Update on Clinical Development.

Am J Clin Dermatol. 2019-6

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Tumor mutational load predicts survival after immunotherapy across multiple cancer types.

Nat Genet. 2019-1-14

[6]
Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma.

Clin Cancer Res. 2018-12-18

[7]
Paget's "Seed and Soil" Theory of Cancer Metastasis: An Idea Whose Time has Come.

Adv Anat Pathol. 2019-1

[8]
Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma.

Cancer Discov. 2018-9-12

[9]
Digital PCR-Based T-cell Quantification-Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma.

Mol Cancer Res. 2018-8-9

[10]
The Role of Histone Deacetylase Inhibitors in Uveal Melanoma: Current Evidence.

Anticancer Res. 2018-7

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